Rising Temperatures Affect Indian Crop Yields

I had a long rant brewing in my head all day about U.S intransigence at the Bali Climate talks, but hell, one massage and a Chimay later, I should just outsource to someone more qualified to lay down the law.

I am going to speak an inconvenient truth. My own country, the United States, is principally responsible for obstructing progress here in Bali. We all know that. We all know that,” he said.

VOA News – Al Gore Blames US for Climate Change Deadlock in Bali

Here’s what pissed me off this morning…

U.S. Strategy Succeeds in Bali
Climate Talks Turn to Efforts Other Than Emissions Targets

BALI, Indonesia, Dec. 13 — U.N. Secretary General Ban Ki-moon conceded Wednesday that the United States had succeeded in achieving one of its key objectives at the climate conference here, blocking a proposal that called on industrialized nations to cut their greenhouse gas emissions by 25 to 40 percent by 2020.

Hmm, this is not even worth a rant. When the capital’s newspaper characterizes behavior that will no doubt result in untold human and material destruction as a “win”, what can be said?

Tags: climatechange, Gore

An update on the benzene story from last month.

Chemical & Engineering News: Latest News – Dispute Over Benzene In Drinks

In late 2005, FDA began analyzing beverages containing benzoate and ascorbic acid. The majority of samples contained either no detectable benzene or levels below 5 ppb, says Robert E. Brackett, director of FDA’s Center for Food Safety & Applied Nutrition. FDA’s results are preliminary. After its survey is complete, the agency will determine what, if any, additional action is necessary, Brackett wrote to EWG. Changes in FDA’s analytical procedures may account for the differences in results. To collect benzene in the earlier tests, FDA used a purge-and-trap method, in which the samples were heated to 100 °C for 30 minutes. Recently, the agency has been using a static-headspace methodology, which does not involve much heat. In the earlier tests, the high heat was probably creating benzene, says an FDA source who asked not to be identified.

The explanation seems to make sense. Low level analysis is riddled with instances such as these, where the analyte you’re looking for is  introduced into the sample after the fact. It is impossible to decide without looking at the protocol whether this happened or not. Since the source of the benzene is from the reaction of ascorbic acid (aka Vitamin C) and benzoate salts, notably sodium benzoate, it would have been clear to anyone doing the analysis to avoid conditions that would result in the formation of benzene during the analysis, or maybe not…

Static Headspace analysis usually involves some heating as well, at much lower temperatures for shorter periods of time, though in the case of something as hydrophobic as benzene, not much heat would be required. So, the artifacts in static headspace would in this case be lower than in purge and trap analysis.

Still not a concern in the grand scheme of aggregate benzene exposure.

ES&T Online News: Can drugs found in water harm humans?

Researchers agree that aquatic species face the greatest risk from exposure to low levels of pharmaceuticals, such as synthetic hormones, which can act as endocrine disrupters at environmental levels. However, little is known about the potential human health effects arising from complex drug mixtures.

Well, it is often more difficult to analyze complex mixtures because Experimental Design 101 makes you want to isolate the effects. And when you do compounds one by one in series, the tendency is to always add them up from the individual experiments. Unfortunately, body chemistry is not like that. I’ve always wanted to design a study that started complex and then tried to isolate later.

To his surprise, Pomati observed that this mixture of drugs at environmental levels inhibited the growth of human embryonic kidney cells. After 48 hours of exposure, cell proliferation was reduced by 10–30% compared with controls. However, no inhibition was observed when cells were exposed to only the toxic cancer drug at environmental levels.

Well, that seems conclusive enough, but here comes the “Experimental Design 101” Scold:

The results show that the growth inhibition is not due to the single most cytotoxic compound alone. But that does not conclusively prove that synergistic or additive effects exist between drugs in the mixture, cautions Thomas Heberer of the Institute of Food Chemistry at the Technical University of Berlin. To show that the individual drugs behave additively, Heberer suggests that researchers should analyze the effects of compounds with a common mode of action, such as antibiotics, alone and in various mixtures.

No, No, and No. Doing this presupposes that you know that mechanism of action, meaning you’ve half answered your question. The question Heberer is trying to answer is “do individual drugs with the same mode of action behave additively”. The question Pomati is trying to answer is “Can we demonstrate cytotoxic effects of a cocktail of drugs at ambient levels in a laboratory setting”? These are two completely different questions and Pomati’s question is more valuable at this point in time. Heberer’s strategy, on the other hand, will keep a lab well funded for years to come! But, it is very much the final step.

It is more important at this point in time to demonstrate other effects such as endocrine disruption, mutagenicity, etc in the lab at environmentally relevant levels of mixtures. Then we can get a better handle on which  effects are relevant and which ones to ignore.

it could happen soon, imagine your car parked in the sun with a plastic solar coating on the roof. Imagine every building surface generating clean electrical energy. Well, it could happen very soon (if hyperbolic sciencedaily press releases are to be believed, at any rate!).

ScienceDaily: New Plastic Solar Cell Breaks Efficiency Record

In order to be considered a viable technology for commercial use, solar cells must be able to convert about 8 percent of the energy in sunlight to electricity. Wake Forest researchers hope to reach 10 percent in the next year, said Carroll, who is also associate professor of physics at Wake Forest.

Because they are flexible and easy to work with, plastic solar cells could be used as a replacement for roof tiling or home siding products or incorporated into traditional building facades. These energy harvesting devices could also be placed on automobiles. Since plastic solar cells are much lighter than the silicon solar panels structures do not have to be reinforced to support additional weight.

Screw ethanol, put all your energy into developing solar and wind energy, battery technology and electric vehicles. See how much better an idea that is compared to corn ethanol.