Cleaner Air Brings Drop in Death Rate – New York Times

Cleaner Air Brings Drop in Death Rate – New York Times

When air pollution in a city declines, the city benefits with a directly proportional drop in death rates, a new study has found.

In other news, Dog bites man (I have never typed “dog bites man” into google news before – shocking…)

Well, the Dockery and company published a seminal set of articles on the 6 city study back in the 90s that are the gold standard of air pollution epidemiology. It takes large long-term studies like these to establish even tenuous correlations, and their graphs connecting particle concentrations and mortality were beautiful straight lines.

This follow up is pretty cool because the cities had made most of the reductions in the 70s and 80s after the passage of the Clean Air Act and this study clearly demonstrates that the bar for lowering mortality/cancer rates by lowering fine particle levels has not been reached yet. The abstract of the paper is below the fold.

Reduction in Fine Particulate Air Pollution and Mortality

Extended Follow-up of the Harvard Six Cities Study

Am. J. Respir. Crit. Care Med. 2006; 173: 667-672

Francine Laden, Joel Schwartz, Frank E. Speizer and Douglas W. Dockery Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health; and Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Rationale: A large body of epidemiologic literature has found an association of increased fine particulate air pollution (PM2.5) with acute and chronic mortality. The effect of improvements in particle exposure is less clear.

Objectives: Earlier analysis of the Harvard Six Cities adult cohort study showed an association between long-term ambient PM2.5 and mortality between enrollment in the mid-1970s and follow-up until 1990. We extended mortality follow-up for 8 yr in a period of reduced air pollution concentrations.

Methods: Annual city-specific PM2.5 concentrations were measured between 1979 and 1988, and estimated for later years from publicly available data. Exposure was defined as (1) city-specific mean PM2.5 during the two follow-up periods, (2) mean PM2.5 in the first period and change between these periods, (3) overall mean PM2.5 across the entire follow-up, and (4) year-specific mean PM2.5. Mortality rate ratios were estimated with Cox proportional hazards regression controlling for individual risk factors.

Measurements and Main Results: We found an increase in overall mortality associated with each 10 µg/m3 increase in PM2.5 modeled either as the overall mean (rate ratio [RR], 1.16; 95% confidence interval [CI], 1.07–1.26) or as exposure in the year of death (RR, 1.14; 95% CI, 1.06–1.22). PM2.5 exposure was associated with lung cancer (RR, 1.27; 95% CI, 0.96–1.69) and cardiovascular deaths (RR, 1.28; 95% CI, 1.13–1.44). Improved overall mortality was associated with decreased mean PM2.5 (10 µg/m3) between periods (RR, 0.73; 95% CI, 0.57–0.95).

Conclusion: Total, cardiovascular, and lung cancer mortality were each positively associated with ambient PM2.5 concentrations. Reduced PM2.5 concentrations were associated with reduced mortality risk.

Key Words: air pollution • cohort studies • follow-up studies • mortality

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    cbs2chicago.com – Agent Orange: A View From Vietnam

    During the eight years of the Vietnam War that the U.S. Military dusted the Vietnamese landscape with Agent Orange, it was only intended to kill vegetation. It was a combination of two herbicides 2,4D and 2,4,5T mixed together into the most potent plant killer ever made. It was spread over 3 1/2 million acres of forests and crops to kill the trees and vegetation so the United States troops could see the enemy. The Armed Forces were told it was harmless. But in March 1978, Bill Kurtis broke the story on CBS 2 that American veterans of Vietnam who had been exposed to Agent Orange were complaining of illnesses, birth defects among their children, skin rashes, cancer, nervous problems and respiratory problems.

    orange3_small.jpgPeople tend to blame dioxins for all the health effects. But 2,4-D and 2,4,5-T, constituents of Agent Orange, are no spring chickens. Exposure during spraying, especially of the grossly excessive amounts that rained down upon Vietnam, can cause various health effects as well, not to mention long-term devastation of entire ecosystems.

    Side note: New Zealand, in 2004, apologized to New Zealand’s “veterans” for their exposure to Agent Orange during the Vietnam war. Not a word to the Vietnamese, of course.

    Side note 2: A US Federal court, in 2005, dismissed the first claims brought by Vietnamese plaintiffs against Dow Chemicals and Monsanto, here was the government’s  reasoning:

    In a brief filed in January, it said opening the courts to cases brought by former enemies would be a dangerous threat to presidential powers to wage war.

    Translation: We reserve the right to drop chemical weapons on our “enemies”, and doing anything to abrogate this right is “dangerous”.

    Image courtesy of Reuters shows a Vietnamese child, one of many with birth defects associated with Agent Orange exposure.

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    California Ban on Diacetyl?

    Flavoring-Factory Illnesses Raise Inquiries – New York Times

    For a good background on flavoring-factory lung disease (formerly known as popcorn worker’s lung), check out the Pump Handle’s many posts, especially this recent one. Short primer, diacetyl is the chemical that gives popcorn its so called buttery taste (and smell, it’s fake!!). Well, there’s pretty good evidence that diacetyl causes bronchiolitis obliterans. Some symptoms…

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