Acrolein Main Cigarette Culprit?

Byoliveridley

Chemical & Engineering News: Latest News – Cigarettes’ Smoking Gun?

Acrolein, one of the 4,000 constituents of cigarette smoke, has been found unexpectedly to cause DNA damage in the gene for the infamous tumor-suppressor p53, which is often disrupted by cancer. In particular, the pattern of DNA mutations caused by acrolein mimics what is often found in human lung cancer samples (Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.0607031103).

“If cigarette smoke is the weapon that causes lung cancer, then these mutations are fingerprints on the knife,” says author Moon-shong Tang of New York University School of Medicine, in Tuxedo. Tang was also involved in identifying another cigarette-smoke component that can induce such mutations: a metabolite of a polycyclic hydrocarbon called benzo[a]pyrene. Acrolein is present in cigarette smoke in levels of up to 1,000 times greater than benzo[a]pyrene.

So, if you remove acrolein from tobacco smoke, does that make for a much safer smoking experience? Is this a research question worth answering? FYI, I watched Thank You for Smoking last night, so, fresh on my mind!

Similar Posts

  • Compare and Contrast these two energy stories

    Byoliveridley

    Read both these stories and go bang your head on a wall repeatedly.

    Europe creates attractive clean energy scene – International Herald Tribune

    But a commitment by European governments to budding clean-energy entrepreneurs is creating a more welcoming environment than in America, where erratic support and onerous financial rules have given pause to some start-ups and investors.

    American ‘Coal Rush’ Hits Some Hurdles

    The nation’s demand for electricity is growing, and utilities want to build new power plants to satisfy that appetite. Most of those plants — perhaps as many as 150 — would burn coal.

    Well, at least the coal rush is hitting a few hurdles. But even if half those plants don’t come about, that’s still 70+ coal fired power plants, nice!

    The interesting part of the IHT story to me was this.

    Venture capitalists and private equity investors in North America have been more bullish, providing $3.5 billion to clean-energy developers in 2006, roughly triple the amount raised in Europe, the Middle East and Africa, according to New Energy Finance, a research firm based in London.

    So, if the US had the right incentives, Americans would be investing there, creating jobs there, improving infrastructure there instead of in Europe. I guess those very “patriotic” American lawmakers don’t think that far ahead. Note also that all the tax cuts to wealthy Americans leaves a lot of cash floating around for them to invest in projects in other parts of the world. These are investments the US won’t reap a benefit on as a country, or create jobs for the working proletariat – Nice tax cuts, more patriotism, I guess. Such a poor return on investment on these tax cuts.

  • | |

    Colonialism: Environmental Edition

    Byoliveridley

    Does put recycling in context…

    Independent Online Edition > Environment

    Regardless of how carefully you separate your waste, there is a good chance a disposal firm will dump it all in together with other kinds of plastic trash and ship it to the developing world to be dealt with by a family of migrant workers earning a pittance. They will deal with the salad-bar container, the pistachio ice-cream container and the superfluous bag for carrots in your shopping basket in a variety of different ways – it may be recycled, it may become landfill or it may simply be burnt. Whatever happens, it is generally not a priority for the waste disposal company. Britain dumps around two million tonnes of waste in China every year, everything from plastic mineral water bottles to shopping bags and other forms of superfluous packaging from some of the country’s biggest supermarkets.

    Same for India as well. The article says that all of this “recycling” is illegal. But how do you hide 200,000 tonnes of plastic waste?

    Read the whole article, it is tragic. Some highlights:

    So too are the many and varied health complaints suffered by the local population, who risk multiple skin ailments and exposure to potent carcinogens as they touch the contaminated materials. Poisonous chemical effluents stream into their water supply, turning it black or lurid red, and studies by Greenpeace show that acid rain is the norm in this region. Children are prone to fevers and coughs. Their skin is often disfigured by the toxic plastic waste they have to process.

    A report by the University of Shantou on the town of Guiyu, another Guangdong recycling hub, showed that more than 80 per cent of local children suffer from lead poisoning.

  • EPA Faces major Challenges, and no money

    Byoliveridley

    At a time when this country faces major environmental challenges, including catching up with the rest of the developed world on global warming, the agency that would have to do the heavy lifting on environmental regulation ain’t getting the money to do diddley squat. A 25% cut in inflation adjusted terms over 4 years is huge, especially considering that the EPA was not a cushy agency even before that.

    ES&T Online News: Budget cuts increasingly damaging to EPA

    Support for research and development at EPA has declined by 25% in inflation-adjusted terms between the recent high point in 2004 and the proposed 2008 budget, according to figures from the American Association for the Advancement of Science.

    “Morale has never been so low here since the days of Ann Gorsuch, and even then there was more money,” says one scientist, referring to the time during the early 1980s when former administrator Gorsuch, who resigned under a cloud, did her best to shrink the agency.

    But George Gray, assistant administrator for the agency’s Office of Research and Development (ORD), says he fully supports the proposed budget. “This budget fulfills every presidential environmental commitment and maintains the goals laid out in the EPA’s strategic plan, while spending less,” he says. The budget cuts come on the heels of EPA’s program to cut $2 million from the agency’s fund for specialized libraries.

    The scientists’ difficulties are likely to increase if the proposals in a June 2006 memo from Lyons Gray, EPA’s chief financial officer, are carried out. The memo, which was released by the advocacy group Public Employees for Environmental Responsibility (PEER) directs ORD to reduce laboratory physical infrastructure costs by a minimum of 10% by 2009 and another 10% by 2011. The memo suggests that this will require closing, relocating, and consolidating EPA’s laboratory and field locations, as well as reducing or relocating staff. ORD chief George Gray told Congress that EPA does not intend to shut down any labs or get rid of any scientists during the current administrator’s tenure.

    The U.S will pay the price for this deliberate destruction of government infrastructure. You won’t see it now, it will be a little more apparent in a few years.

  • US, India and China Talk Climate

    Byoliveridley

    The Obama administration is hoping to win new commitments to fight global warming from China and India in back-to-back summits next month, the Guardian has learned, including the first Indian emissions trading scheme.

    The US hopes the new commitments will breathe life into the moribund negotiations to seal a global treaty on climate change in Copenhagen in December, by setting out what action each country will take. But many observers say such bilateral deals also risk seriously weakening any Copenhagen agreement by allowing the idea of a global limit on greenhouse gas emissions to be abandoned.

    The Guardian

    So, as part of Blog Action Day 2009, which is focusing on climate change, I bring you news that the US administration is back, taking some kind of a leadership role in climate change by talking to India and China. The notion that somehow what the US, Europe and Canada do in response to climate change is pointless because China and India are not going to participate is misleadingly inaccurate, sometimes deliberately so. I had written in June about India’s very ambitious solar policy, and China has similar, fairly comprehensive programs on climate change.

    The concern that bilateral talks will somehow sabotage the multilateral Copenhagen negotiations is, I think, overstated. More talk is always better, and good things happen when the world’s most high profile polluter signals its willingness to talk, and even initiate talks with countries whose development paths are at a critical stage.

    I have not been super hopeful about how things are going to turn out in the next few years. But things have changed quite a bit in the past year. The US appear to have their own climate bill brewing. Europe makes the right noises and has a head start,making the mistakes early. Unfortunately, Canada has given up the ghost thanks to our troglodyte oil man administration. Our main hope now is that the US passes a strong enough bill to affect Canada. Or there is an election leading to a change in administration and Mr Michael Ignatieff and the “liberals” are true to their word on a new, sustainable energy policy.

    Canada is now the worst laggard, having extremely high per capita emissions and policy to increase these emissions while actively sabotaging climate talks. We emit a full 2% of all global warming contributors while accounting for about 0.5% of the world’s population. It is understandable given our development path how we got there, but not trying to fix it is criminally negligent and morally bankrupt.

    Apparently, the Canadian people could care less, polls indicate that the business as usual administration is increasing its support among Canadians. What is the average Canadian’s responsibility if he/she knowingly supports policy that could lead to mass homelessness, flooding, starvation, wars, species extinction, etc?

    On Climate blog action day, I am sad to report that my adoptive country will do nothing but soldier on in its destructive behaviour. No point calling my local MP, she agrees with me!

  • More signs of the rapture – Fish dying in the Great Lakes

    Byoliveridley

    Freaky and scary, first the bees, now the fishes…

    Fish-Killing Virus Spreading in the Great Lakes – New York Times

    A virus that has already killed tens of thousands of fish in the eastern Great Lakes is spreading, scientists said, and now threatens almost two dozen aquatic species over a wide swath of the lakes and nearby waterways.

    The virus, a mutated pathogen not native to North America that causes hemorrhaging and organ failure, is not harmful to humans, even if they eat contaminated fish. But it is devastating to the ecosystem and so unfamiliar, experts said, that its full biological impact might not be clear for years. It is also having a significant impact on the lakes’ $4 billion fishing industry.

    There is no known treatment for the virus. As a result, scientists are focusing on managing its spread to uncontaminated water — quite a challenge since the Great Lakes are linked and fall under the jurisdiction of several states and provinces in Canada.

  • The emperor's "new" climate policy

    Byoliveridley

    You mut have heard by now that the emperor of the US (I call him that because he thinks he is above the law and rules by fiat) announced a new meeting to tackle climate change issues. David Roberts of Grist broke it down and concluded that it was worse than nothing. It rejects targets, groups China and India with the developed world, which ensures that nothing will ever come out of his “meeting”, kicks everything down the road until after he has abdicated his throne in 2009, and tries to take advantage of climate change to push for free trade deals.

    But this article by Dana Milbank of the Washington Post caught my attention for the rather surreal exchange between a CBS reporter and the White House spokesman.

    Dana Milbank – As the World Warms, the White House Aspires – washingtonpost.com

    In this instance, you have a long-term, aspirational goal,” Connaughton answered.

    Aspirational goal? Like having the body you want without diet or exercise? Or getting rich without working?

    “I’m confused,” Axelrod said. “Does that mean there will be targets for greenhouse gas emission reductions, and that everybody will be making binding commitments?”

    “The commitment at the international level will be to a long-term, aspirational goal,” the Bush aide repeated.

    Axelrod had his answer. “Voluntary,” he concluded.

    “Well,” said Connaughton, “I want to be careful about the word ‘voluntary.’ “

    Yes, please do be careful, let’s not over promise and under deliver like we always do!

    Connaughton may want to be careful, but the plan the White House outlined yesterday listed no concrete targets or dates, no enforcement mechanism and no penalties for noncompliance. It also wouldn’t take effect until four years after Bush leaves office. It was, rather, a call to spend the final 18 months of the Bush presidency forming an aspirational goal.

    Umm, we’re not in 1985 any more, aspirational goals have long since been established, stabilization at 450 ppm C anyone?

    I love the emperor and his merry band of climate advisers!