Great News, but Innovative, Really?

The “innovation” in this approach is not scientific, but economic.

Cheap drugs for poor nations | Guardian Weekly | Guardian Unlimited

Improvements they devise to the molecular structure of an existing, expensive drug turn it technically into a new medicine that is no longer under a 20-year patent to a multinational drug company and can be made and sold cheaply. The process has the potential to undermine the monopoly of the big drug companies and bring cheaper drugs not only to poor countries but back to the UK.

Okay, I may be missing something here, but this is not a scientifically innovative strategy. They are called Me-Too drugs. Pharma has been doing this for years. Read this article in the Stanford Medicine Magazine about exactly how this is done.

Nexium illustrates the drug makers’ strategy. Many chemicals come in two versions, each a mirror image of the other: an L-isomer and an R-isomer. (The “L” is for left, the “R” is for right.) Nexium’s predecessor Prilosec is a mixture of both isomers. When Prilosec’s patent expired in 2001, the drug maker was ready with Nexium, which contains only the L-isomer.

Is Nexium better? So far,

there’s no convincing evidence that it is, says Stanford drug industry watcher Randall Stafford, MD, PhD.

This is a well known and well used strategy. The Government Accounting Office (GAO) recently released a study which concluded that 68% of all drugs developed in the US between 1993 and 2004 were Me-Toos.

So, what is “innovative” and “revolutionary” about this approach is that non-profits are driving the drug development. By outsourcing the entire clinical trial to India, substantial savings are to be had. By not having to fund the US shareholders’ need for huge profits, enormous company overhead, high salaries, multi million dollar executive bonuses and marketing expenses that US/European pharma require, cost savings are potentially huge.

The downside? Well, unless the studies are run according to US/EU GLP/GMP guidelines, data quality, and therefore, drug safety can be suspect. The pedigree of the people involved in this effort makes it unlikely that the data is going to be suspect. If their ultimate aim is to sell these drugs in England, then they will have to meet the most stringent standards available.

Of course, these drugs will never hit the US of A. I can already hear the fear mongering, the safety doubts being raised, the “terrorists may get their hands on your pill” bogey, etc. But, Americans can afford to pay for their drugs more than your average Indian suffering from Hepatitis C can. Once the already teetering (by first world standards, of course!) healthcare system in the US gets closer to collapse (by first world standards, of course!), some of these “innovations” will become more viable in this most reactionary of countries.

I hope this model is proven to be viable.

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    Water Find to End Darfur War – Well, not so fast!

    Beware the dangers of the overhyped press release machine (or sciencedaily, pick your poison). All Farouk El-Baz saw when he did the radar study was a giant depression. It is TBD whether there’s water in them thar holes!’

    BBC NEWS | Africa | Ancient Darfur lake is dried up

    Alain Gachet, who used satellite images and radar in his research, said the area received too little rain and had the wrong rock types for water storage. But the French geologist said there was enough water elsewhere in Darfur to end the fighting and rebuild the economy.

    On Wednesday, Boston Universitys Farouk El-Baz said he had received the backing of Sudans government to begin drilling for water in the newly-discovered lake, in North Darfur.

    No wonder they say that water is the 21st century oil. This guy’s going to be drilling for water (also known as well digging!).

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    China takes most of UN clean energy funds

    Clean Power That Reaps a Whirlwind – New York Times

    That program, the Clean Development Mechanism, has become a kind of Robin Hood, raising billions of dollars from rich countries and transferring them to poor countries to curb the emission of global warming gases. The biggest beneficiary is no longer so poor: China, with $1.2 trillion in foreign exchange reserves, received three-fifths of the money last year. And as a result, some of the poorest countries are being left out.

    Scientists increasingly worry about the emissions from developing countries, which may contribute to global environmental problems even sooner than previously expected. China is expected to pass the United States this year or next to become the world’s largest emitter of global warming gases.

    The controversy is that China, India and Brazil together are gobbling up close to 80% of the UN Clean Development Mechanism Funds. What is the CDM?

    The Clean Development Mechanism (CDM) is an arrangement under the Kyoto Protocol allowing industrialized countries with a greenhouse gas reduction commitment (so-called Annex 1 countries) to invest in emission reducing projects in developing countries as an alternative to what is generally considered more costly emission reductions in their own countries.

    In theory, the CDM allows for a drastic reduction of costs for the industrialised countries, while achieving the same amount of emission reductions as without the CDM. However, critics have long argued that emission reductions under the CDM may be fictive, and in early 2007 the CDM came under fire for paying €4.6 billion for destruction of HFC gases while according to a study this would cost only €100 million if funded by development agencies.

    Source wikipedia.
    The Kyoto protocol was supposed to be a starting point for further negotiations. Unfortunately, the U.S pulled out and put negotiations towards a better worldwide mechanism on the backburner.

    Back to the issue at hand? This program is supposed to help countries that are expanding their energy use fast to develop clean sources of energy. India and China are both developing at breakneck pace, and every bit of wind energy that goes in there is one less Megawatt from coal. Yes, the money is not going to Africa, but Africa is not developing infrastructure at that pace (the reasons for that have filled many books!). This program is not meant to foster development, it is meant to facilitate clean development wherever development occurs. So, if China is developing the fastest, it has equal rights to access these funds to put in a wind energy infrastructure.

    If you want China and India to stop using these funds and use some of their own money to develop clean energy, you have to redesign the program to include a rider that takes into account the affluence of the country. The more money a country has, the less it gets from the CDM, or it has to atleast pony up a bigger share. You also have to put in the infrastructure in poorer countries that can take advantage of these funds. Without a power distribution infrastructure, or a functioning government or bureaucracy, how do you expect a poor country in Africa to take advantage of a complicated credits based funding program?

    Development is complicated stuff, and distortions like these happen all the time. When the Kyoto protocol was negotiated, China was not rich, now it has a little more money. Development situations are fluid and demand flexibility in action, and constant monitoring. If the world’s richest country does not participate, and actively trashes the UN continuously, old and imperfect agreements stay in power even longer. U.S disavowal of the Kyoto protocol has the effect of making the protocol’s distortions even stronger and delaying action to fix them.

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    Canada loves asbestos (in third world lungs)

    In a normal world, when something is severely restricted in your country, you would not export it to another country under the pretense that used under certain, very restricted conditions, your product only causes a moderate increase in cancer.

    While the federal government projects an image of being a helpful, international Boy Scout on issues ranging from peacekeeping to nuclear proliferation, Canada has a peculiar relationship to asbestos.

    globeandmail.com: Asbestos shame

    But we don’t live in a normal world, because asbestos is exported from Canada to India where it is added to cement.

    Tushar Joshi, a noted New Delhi occupational health expert, is flabbergasted over asbestos sales by a country of Canada’s stature. “As a developed country, you expect more civilized behaviour,” Dr. Joshi says. Canada’s activities are “beyond comprehension,” he adds, calling Ottawa’s promotion of asbestos “a black spot on a sparkling white dress.”

    yes, well said. It is very mysterious that asbestos use in India went up in the 1980s just as evidence about its incredibly destructive effects on respiratory systems had curtailed use in most of the first world. Clearly, third world lungs are not as important as Canadian lungs.

    Asbestos is one area where Canada lags even behind the US. And Canada’s environmental practices are going to come under increasing scrutiny as climate change unfreezes the great white North and exposes the resources underneath.

    Canada, the world is watching.

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    North Carolina to establish birding trail

    This is good news, maybe just the ticket to reawaken my long dormant birdwatching predelictions. The money this brings in will doubtless fund the continued existence of wetlands and other endangered habitats.

    newsobserver.com | Beauty, bucks sought in bird trail

    SWANSBORO – With hundreds of colorful birds already visiting and calling Eastern North Carolina home, the state is encouraging bird lovers to bring their binoculars and billfolds to watch them. The N.C. Birding Trail unveiled this week links dozens of sites long known to birders as packed with rare, popular or threatened species, such as the endangered red-cockaded woodpecker.

    But state officials are promoting the trail as nature-themed tourism and hope it will give the financially stressed region an economic boost.Forget the notion of birdwatching as a sedate, nerdy activity. Now hunting and fishing guides are running bird charters and bird-related tourism is worth millions.

    “We have people coming here from all over the country,” said John Ennis of Brunswick County, eastern vice president of the Carolina Bird Club. “It’s a great resource.”

    When completed, the North Carolina trail will include dozens of places across the state that visitors can reach by car and look for more than 440 species of birds.

    The first section, which highlights the coastal region, includes 102 birding sites in 16 groupings east of Interstate 95. A Piedmont trail that will bundle sites between Interstate 95 and Interstate 77 is scheduled to be completed next year with a mountain trail slated after that.

    At least 100 sites have already been approved for the Piedmont section with three dozen in the Triangle. Birders will be directed to state and local lands such as Hemlock Bluffs Nature Preserve in Cary, Raleigh’s Lake Johnson Park, Eno River State Park in Orange County and Duke Forest in Durham County.

    Salinda Daley, N.C. Birding Trail Coordinator, said that describing the program as a trail causes some misunderstanding because it is not just lines on a map. She said promotional material links spectacular bird watching sites and birders with communities and businesses.

    hey, who’re you calling a nerd!!

  • |

    The most important thing I read today (Indian Agriculture Edition)

    Yes, I read the Times article about this subject too, but Tom Philpott and P. Sainath writer better and more eloquently.

    India, food, and modernization | Gristmill: The environmental news blog | Grist

    That “promising biotechnology” is Monsanto’s Bt cotton seed, genetically modified to ward off the cotton bollworm. Indian farmers have been desperate to get their hands on it because they think they need it to compete with their lavishly capitalized and subsidized U.S. peers.

    But the Monsanto seed, which promises to enable farmers to use 25 percent less pesticide, might not be worth the premium (it goes for about twice as much as conventional seed, the Times reports). The great Indian journalist P. Sainath wrote recently that “despite all the claims made for [Bt cotton], input dealers here have seen no decline in pesticide sales as a result of its use. Some claim higher sales than before.”

    As prices for seeds and other inputs rise, farmers have seen the price their goods fetch in the marketplace fall or stagnate. The result has been crushing debt burdens, mounting losses, and a stunning surge in suicides among farmers.

    The Times reports that “17,107 farmers committed suicide in 2003, the most recent year for which government figures are available. Anecdotal reports suggest that the high rates are continuing.”

    Well, that’s one way to clear the land of “inefficient” farmers.

    For the enduring scam that is BT cotton, read this.

  • Chart of the Day – The Arms Trade

    asales1.png
    This is a chart for arms sales by country in 2005. USA is currently tops by far, but if you read the accompanying Boston Globe article from last year, Russia’s trying very hard to catch up.

    This is the oxygen that keeps conflicts going a lot longer than they should, and also make them so much more destructive. Remember this when your favorite government (they’re all to blame here, no singling one country out) starts talking about “peace”.

    Happy Friday!!

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