More bad news for Nalgene

Nalgene, and other so called safe hard plastics made from polycarbonates. Read here for background and all previous Bisphenol A postings.

PLoS Genetics – Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse

In the course of studies to assess the effects of BPA on the mouse oocyte, we have uncovered a novel “grandmaternal” effect: exposure to BPA during pregnancy disturbs oocyte development in unborn female fetuses. When these fetuses reach adulthood, the perturbations are translated into an increase in chromosomally abnormal eggs and embryos. Thus, low-dose BPA exposure during pregnancy has multigenerational consequences; it increases the likelihood of chromosomally abnormal grandchildren. Our studies also provide mechanistic insight, and, surprisingly, suggest that BPA acts in the fetal ovary not by mimicking the actions of estrogen but by interfering with the function of one of the known estrogen receptors. Thus, our data suggest that estrogen plays a far earlier role in oocyte development than previously suspected and, importantly, raise the possibility that a variety of substances—both synthetic and naturally occurring—that mimic the actions of estrogen or act as estrogen antagonists may affect early oocyte development.

Once again, caution is involved in the interpretation of the results, mice are more sensitive than humans to environmental exposures. The heartening part of this, and other recent studies is that work is now being carried out at doses that are more representative of ambient exposures, making results much more relevant. The part in bold is equally interesting. Estrogen is a very powerful hormone that has so many unknown effects on the body (and the mind, presumably :-;)

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