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An off patent miracle cancer cure?

Interesting news coming out of Canada from a Dr. Anselm at the University of Alberta about a well known chemical dichloroacetic acid (like vinegar with two chlorines!).

Cheap, safe drug kills most cancers – health – 17 January 2007 – New Scientist

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Here’s the PubMed citation for the article, filled with biology I will have no hope of understanding! I read the press release on sciencedaily a few days back and did a little background digging.

A clinical trial conducted by Colombia University studying the effects of dichloroacetate on MELAs (stroke like symptoms) was halted early because everyone taking the medication showed significant effects of neural toxicity. This study was commented on by Dr. Anselm who theorized that the effect could be caused by a specific gene mutation not seen in a lot of the patients he works with.

So, there is some reason for caution on this wonder drug, it may be toxic at certain doses to certain people. Most chemotherapetic drugs are horrendously toxic too. But if this is not a concern, Dr Anselm, meet Sunil Shaunak and his wonderful proposal to setup an alternative pipeline for drug approval that does not involve big/small pharma. I Am sure between Bill Gates, or George Soros, a few million bucks can be rustled up for a cancer cure.

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  • Smoking bans

    If you followed the failed attempt in North Carolina this year to ban smoking in indoor public spaces, one of the so called arguments was the famous slippery slope one, that this was only a prelude to banning smoking “in the comfort of your own home”, and other attendant property rights arguments. Well, it turns out that there is an impromptu smoking ban in place in most homes already!

    Study: Smoking forbidden in most U.S. households – CNN.com

    Smoking is forbidden in nearly three out of four U.S. households, a dramatic increase from the 43 percent of homes that prohibited smoking a decade ago, the federal government reported Thursday.

    Before anyone makes the property rights argument that this “ban” is by choice, and not by government fiat, let me make it, and break it. Smoking falls into the category of occupational and reccreational exposure to pollution that harms and kills. It’s no different from lead in the water or smog as far as the non-smoker is concerned. So, property rights are not polluter rights, sorry.

    It’s only a matter of time before smoking indoors is considered completely and utterly unacceptable, kinda like smoking in airplanes!

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    FDA decides to breed super bugs

    Well, what else can you say about it. This is insanely moronic. Read this sierra club release about the overuse of antibiotics brought on by the overcrowding of animals in food production factories (aka “farms”). Read the whole article and see how much everyone will be endangered so that Intervet, Inc. can make money.

    FDA Rules Override Warnings About Drug – washingtonpost.com

    The government is on track to approve a new antibiotic to treat a pneumonia-like disease in cattle, despite warnings from health groups and a majority of the agency’s own expert advisers that the decision will be dangerous for people. The drug, called cefquinome, belongs to a class of highly potent antibiotics that are among medicine’s last defenses against several serious human infections. No drug from that class has been approved in the United States for use in animals.

    Note, a powerful and potent antibiotic that works well, but is not used much because it’s the last line of defense. But the drug company that manufactures this product cares little about long term efficacy. Their only goal is to maximize short term shareholder value. I don’t blame them, I blame the government for not doing its job, that is, to balance these short term and long term goals and protect the people that pay them a lot of money for this protection.

    The wording of “Guidance for Industry #152” was crafted within the FDA after a long struggle. In the end, the agency adopted language that, for drugs like cefquinome, is more deferential to pharmaceutical companies than is recommended by the World Health Organization.

    Cefquinome’s seemingly inexorable march to market shows how a few words in an obscure regulatory document can sway the government’s approach to protecting public health.

    There’s a reason this present U.S government works in secrecy, so these “obscure” (I am sorry, but nothing that directly affects human health can be called obscure) rule changes will not hit the public eye before it’s too late. Apparently, the FDA can now only consider resistance to food borne diseases in considering an application. That’s like saying that a hospital will only treat victims of food borne diseases, so if you catch the cold, we won’t treat you! This is the Food and Drug Adminstration (all food and all drugs), not the food borne disease protection council.

    This drug is absolutely unnecessary for the following reasons:

    1. The disease it treats (respiratory distress in cows) is brought about by insane levels of animal overcrowding
    2. There are currently a dozen antibiotics for this particular problem, none of which are considered susceptible to resistance
    3. The FDA has previous history with similar public health threats with fluoroquinolones
    4. This drug is considered a last resort drug for antibiotic resistant strains of diseases in cancer patients – So strains resistant to this drug will evolve shortly after the antibiotic is overexposed . This is a death sentence for a lot of very vulnerable people.
    5. A similar drug used in Europe for the last 10 years has resulted in an increase in resistant strains of bacteria.

    This is what you get when you vote for an ideology that hates government. You get a government that hates itself and is busy pawning parts of itself off to its cronies.

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    Black Lung – Miners pay so you can get more coal

    The Pump Handle alerts us to a special report on coal miners and their lungs, not for the faint of heart, but something to keep in mind when you hear the phrases “Cheap Energy” and “coal” in one sentence, it’s not so cheap for these people.

    Black Lung: Dust Hasn’t Settled on Deadly Disease « The Pump Handle

    Louisville-Courier Journal reporters Laura Unger and Ralph Dunlop offer us the voices and faces of miners who are suffering from coal workers’ pneumoconiosis. Their special report, Black Lung: Dust Hasn’t Settled on Deadly Disease, includes an on-line version which features five compelling videos featuring 40- and 50-year old coal miners who are now suffering with the disabling lung disease. Mr. Danny Hall, 56, for example, who is still severely impaired despite receiving a lung transplant says “if I had to do over, I wouldn’t ever go into coal mining.”

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    March Babies not so Bright? – Pesticides to Blame?

    An Indiana scientist makes a rather provocative argument that exposure to pesticides in the womb can explain why Indiana babies conceived in July-August (Born March and April?) have lower achievement scores than the other kids.

    ScienceDaily: Conception Date Affects Babys Future Academic Achievement

    Dr. Winchester and colleagues linked the scores of the students in grades 3 through 10 who took the Indiana Statewide Testing for Educational Progress (ISTEP) examination with the month in which each student had been conceived. The researchers found that ISTEP scores for math and language were distinctly seasonal with the lowest scores received by children who had been conceived in June through August.

    “The fetal brain begins developing soon after conception. The pesticides we use to control pests in fields and our homes and the nitrates we use to fertilize crops and even our lawns are at their highest level in the summer,” said Dr. Winchester, who also directs Newborn Intensive Care Services at St. Francis Hospital in Indianapolis.

    “Exposure to pesticides and nitrates can alter the hormonal milieu of the pregnant mother and the developing fetal brain,” said Dr. Winchester. “While our findings do not represent absolute proof that pesticides and nitrates contribute to lower ISTEP scores, they strongly support such a hypothesis.”

    Well, that is a bold leap of faith, and use of a correlation=causation argument that I don’t appreciate in most cases. Has this kind of work been done in other countries, or in urban environments without pesticide use?

    I am sure that many chemicals have subtle, but significant effects on developing fetuses. And the chemicals the authors mention have links with hypothyroidism..

    Nitrates and pesticides are known to cause maternal hypothyroidism and lower maternal thyroid in pregnancy is associated with lower cognitive scores in offspring.

    There is a link, but without further data, I think the conclusions are a stretch. But, something to keep in mind I guess if you live in Indiana and want to plan a baby!

    Disclaimer: I was conceived in June, and was in the upper echelons of achievement through school. So, by the power of personal experience, I am predisposed to scepticism. OTH, I grew up in a big city with consistently high pollution levels throughout the year and not much pesticide exposure.

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    Break the link between employment and healthcare!

    Cross-posted from Interrobang:

    The US Supreme Court ruled along political lines on the 30th of June, 2014 that “closely held corporations”, over 90% of all US businesses, are now free to discriminate against women (and it was specifically women and birth control) if their religion leads them to believe birth control kills babies, or that women who use birth control are Satan’s spawn (the belief does not have to be factual).

    The Supreme Court says corporations can hold religious objections that allow them to opt out of the new health law requirement that they cover contraceptives for women.

    The justices’ 5-4 decision Monday is the first time that the high court has ruled that profit-seeking businesses can hold religious views under federal law. And it means the Obama administration must search for a different way of providing free contraception to women who are covered under objecting companies’ health insurance plans.

    Salon AP coverage

    I am not going to debate the wrongness of this decision, the notion that businesses can have religious beliefs, and can use them to discriminate against certain types of people is not up for debate. And, the discrimination is very specific and targeted…

    The other, more ubiquitous discrimination is in the notion that the health care you get has anything to do with the work-for-pay arrangement you have with the organization you work for. I am probably the millionth person to mention this, and whole books have been written on the subject, but, the link between healthcare and your employer is wrong because it anchors discrimination. This particular egregious case goes one step further and discriminates based on gender as well, not just work status.

    The US had a chance to sever health benefits from employment when they had a three-year debate on expanding health insurance coverage. Thanks to the ability of small political minorities to filibuster and block action, and a corporate-funded reluctance for change, the US kept their employer-based health insurance system in place, and with it, all the discrimination that entails. Uwe Reinhardt reiterated a number of these points recently in the New York Times.

    Back Home

    Is BC any better? Yes and no. Thanks to Canada’s Medicare, parts of our health care system are universal and not subject to employment ties. But, there are several exceptions making us a two-tier health care system:

    1. The health insurance tax or MSP (what our government cutely calls a “fee” in order to not call the yearly increase in this fee a tax increase): Many employers will pick up part/all of this tax for their employees, whereas one that doesn’t can pay more than 1000 dollars a year for a family. While there is an element of progressiveness to the pricing with very low-income people paying less/nothing, it is weak, families making > 30K per year pay full price.
    2. Drugs: For some reason, drugs are not covered by our “universal” healthcare system and are provided by workplace “supplemental benefits”, as if taking a thyroid pill every day is a “supplement”. The CCPA makes an excellent case for universal pharmacare, if you need more convincing. 10% of Canadians cannot fill prescriptions for financial reasons.
    3. Our public health insurance system assumes people don’t have eyes or teeth. So, if you want your cavities filled, a root canal, or want to see clearly, you need “supplemental benefits”, and these are mostly employer-provided. Oral health is a clear marker of health inequality.
    4. Mental health is not covered, this is inexcusable, as Andre Picard notes.
    5. Treatments that improve overall health, like massages, are not really covered. Once again, your employment status determines whether you have the “luxury” of holistic preventative measures to reduce stress, pain, and many other issues.
    6. Historically and currently oppressed groups, Canada’s indigenous people for example, get a short shrift on the benefits like massage, nutrition, counselling and holistic treatment they need because of disparity in employment availability.

    This quote from the Andre Picard article I mentioned summarizes the discrimination.

    The well-to-do pay. The middle-class scrape together the money the best they can, sacrificing so their child can get care. And those without the means wait, or do without care.

    There are other side-effects. Because “benefits” are expensive, companies have a vested interest in only having certain “valuable” employees benefit. The rest get treated as contractors, have their hours strategically reduced, and much more.

    It’s almost as if there’s an unspoken moral argument here, you don’t deserve good teeth or a massage if you don’t work for a living.

    Yes, you can buy individual supplemental insurance, or pay per use, but neither of these are cheap because you as an individual have no bargaining power.

    We in BC also have a long way to go to break the link between healthcare and employment. Will it cost the average BC resident more money? Let’s consider:

    1. A simpler system with one buyer is administratively efficient. It takes the thousands of decision points every HR administrator or group in every company/union has to make and transfers that to a single entity. Public universal plans are about four to ten times more efficient (pdf) than fragmented private plans.
    2. A bigger entity can negotiate much better rates for you, whether it is for drugs, or for dentistry, or for anything else (a bigger risk pool). If all of Canada administered one simple pharmacare system, we would negotiate much lower prices with pharmaceutical companies. We would also have better funding to run and evaluate effectiveness studies.
    3. Funding preventative, holistic healthcare means fewer hospital visits. In a universal system, there are no artificial barriers between a massage, drug treatment, surgery, stress reduction counselling, or ergonomic counseling for back pain. You don’t have to prove your work injured you in order to get the right treatment, your first point of contact with a medical professional (not necessarily a doctor) decides which path works best. You do not have to get sick enough to go to the hospital before you get treatment covered by insurance.

    Pitfalls

    There are concerns with a universal single-payer system:

    1. As Vox points out, if a government administering the single-payer system decides not to pay for contraception, then no one gets it. So, getting good universal healthcare is about constantly winning political battles. The good thing about universal healthcare in Canada is that it is incredibly popular, polling near 90% approval (pdf). So once quality is improved, governments will find it hard to cut back.
    2. Like any other public system, the quality of the institutions drafting policy and administering the system is vitally important. Well run public systems are efficient. But conservative movements in the last 30+ years have worked hard to dismantle the quality of public institutions and trust in such institutions. In this reality of shrinking budgets and staff levels where bureaucrat is a term of insult, ensuring that public system expansion is handled efficiently is no given. There is an entire industry of political parties, think tanks and media devoted to tearing down the concept of a publicly administered good, and ready to pounce on every little misstep (Remember the Obamacare roll out anyone?)
    3. Will employers raise wages from all the savings they get from not providing health benefits, and will these raises cover the increase in taxes we will pay for universal healthcare? Probably not right away, but it will happen eventually.

    Transitions

    Clearly, we can’t transition tomorrow. A public system would need to be in place and functioning before our employers get out of the health insurance business. I would phase universality in the following order:

    1. Drugs
    2. Teeth and eyes
    3. Preventative and palliative care.

    We would also need to rethink the”fee for service”, where healthcare providers are paid per widget, and think about a different system closer to a salaried model, more on that in future blog posts.

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