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An off patent miracle cancer cure?

Interesting news coming out of Canada from a Dr. Anselm at the University of Alberta about a well known chemical dichloroacetic acid (like vinegar with two chlorines!).

Cheap, safe drug kills most cancers – health – 17 January 2007 – New Scientist

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Here’s the PubMed citation for the article, filled with biology I will have no hope of understanding! I read the press release on sciencedaily a few days back and did a little background digging.

A clinical trial conducted by Colombia University studying the effects of dichloroacetate on MELAs (stroke like symptoms) was halted early because everyone taking the medication showed significant effects of neural toxicity. This study was commented on by Dr. Anselm who theorized that the effect could be caused by a specific gene mutation not seen in a lot of the patients he works with.

So, there is some reason for caution on this wonder drug, it may be toxic at certain doses to certain people. Most chemotherapetic drugs are horrendously toxic too. But if this is not a concern, Dr Anselm, meet Sunil Shaunak and his wonderful proposal to setup an alternative pipeline for drug approval that does not involve big/small pharma. I Am sure between Bill Gates, or George Soros, a few million bucks can be rustled up for a cancer cure.

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  • Doctors Take Bribes to Prescribe Drugs

    This is the headline I would have used on this story. An incentive scheme to use a paticular product in a situation like this is a bribe.

    Doctors Reap Millions for Anemia Drugs – New York Times

    Two of the world’s largest drug companies are paying hundreds of millions of dollars to doctors every year in return for giving their patients anemia medicines, which regulators now say may be unsafe at commonly used doses.

    The payments are legal, but very few people outside of the doctors who receive them are aware of their size. Critics, including prominent cancer and kidney doctors, say the payments give physicians an incentive to prescribe the medicines at levels that might increase patients’ risks of heart attacks or strokes.

    Industry analysts estimate that such payments — to cancer doctors and the other big users of the drugs, kidney dialysis centers — total hundreds of millions of dollars a year and are an important source of profit for doctors and the centers. The payments have risen over the last several years, as the makers of the drugs, Amgen and Johnson & Johnson, compete for market share and try to expand the overall business.

    So how does this kickback scheme work?

    Federal laws bar drug companies from paying doctors to prescribe medicines that are given in pill form and purchased by patients from pharmacies. But companies can rebate part of the price that doctors pay for drugs, like the anemia medicines, which they dispense in their offices as part of treatment. The anemia drugs are injected or given intravenously in physicians’ offices or dialysis centers. Doctors receive the rebates after they buy the drugs from the companies. But they also receive reimbursement from Medicare or private insurers for the drugs, often at a markup over the doctors’ purchase price.

    Medicare has changed its payment structure since 2003 to reduce the markup, but private insurers still often pay more. Combined with those insurance reimbursements, the rebates enable many doctors to profit substantially on the medicines they buy and then give to patients.

    The rebates are related to the amount of drugs that doctors buy, and physicians that agree to use one company’s drugs exclusively typically receive higher rebates.

    Wow, that’s a scheme that would be illegal in almost any situation. I buy 10 widgets from the manufacturer for $100. The manufacturer then gives me $50 in “rebate”. I charge the person on whose behalf I am buying these widgets $200 even though I am not supposed to make a profit on this transaction, and pocket $150 from a transaction. I also promise to use more of this widget, on people who may or may not need it, but on whom I have such a knowledge gap and power gap that I know that they will use it whether it is actually good for them or not. I also promise not to use a competitor product even though I know that there are cases where one product will be better than the other. Well, who pays, all of us in increased health insurance premiums and healthcare costs so a bunch of rich doctors can drive their Range Rovers around.

    The USA is no different from India when it comes to schemes like this. The money involved is greater, and somehow, this is not called a bribe by the media.

    What does the pharma spokesperson have to say?

    Johnson & Johnson said yesterday in a statement that its rebates were not intended to induce doctors to use more medicine. Instead, the rebates “reflect intense competition” in the market for the drugs, the company said.

    Amgen said that rebates were a normal commercial practice and that it had always properly promoted its drugs.

    Yes, it’s competitive out there, and to ensure that our product gets used, we will bribe people.

    The “consumer” is the person who pays for the product or service. The “consumer” here is the end user, the patient. The patient does not get the rebate, instead having to pay high prices so doctors can add to their six figure incomes. Nice!

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    Melamine Adulteration investigation gets cracking

    FDA agents raid pet food plant, offices – Yahoo! News

    WASHINGTON – Federal agents searched facilities of a dog and cat food manufacturer and one of its suppliers as part of an investigation into the widening recall of pet products, the companies disclosed Friday. Food and Drug Administration officials searched an Emporia, Kan., pet food plant operated by Menu Foods and the Las Vegas offices of ChemNutra Inc., according to the companies. Menu Foods made many of the more than 100 brands of pet food recalled since March 16 because of contamination by the chemical melamine. ChemNutra supplied the manufacturer with wheat gluten, one of the two ingredients tainted by melamine used in recalled pet products. Both companies said they were cooperating with the investigation.

    The initial “let’s blame China for everything” drumbeat is subsiding a little as the FDA finally begins its inspections, and we find the tangled web of the food import business unraveling just a little bit. At this point in time, the charges are flying like crazy.

    The origin within China of the wheat gluten and rice protein concentrate remains murky. For example, ChemNutra’s source for the twovegetable proteins, Suzhou Textile Import and Export Co., told The AP that food ingredients aren’t part of its business — but that employees often take on side deals. Stern said ChemNutra dealt with the company’s president.

    Side deals? How quaint? The solution is simple: Quarantine every food item from China until it has been tested for melamine. You do not know the extent of the problem yet. It only seems to get worse everyday. Make the manufacturers pay for the testing.  Tighten up the paperwork, exercise tighter control over where the ingredients come from, get everything in writing.

    Meanwhile, the manufacturers are getting their press releases out. From Blue Buffalo foods…

    We at the Blue Buffalo Company have just learned that American Nutrition Inc. (ANI), the manufacturer of all our cans and biscuits, has been adding rice protein concentrate to our can formulas without our knowledge and without our approval. This is product tampering, and it apparently has been going on for some time. The can formulas that we developed, and trusted them to produce, never contained any rice protein concentrate. It appears that only an FDA investigation of ANI’s rice protein concentrate supplies forced them to reveal this product tampering to us.

    While this activity by ANI is in itself unlawful, the situation is further clouded by the fact that ANI has been receiving rice protein concentrate from Wilber-Ellis, some of which the FDA has determined to be contaminated with melamine.

    If this is true (and we don’t know that for a fact), it’s plain ol’ cheating and food adulteration. What does American Nutrition have to say?

    The FDA has urged American Nutrition to issue a voluntary recall of pet foods manufactured using Wilbur-Ellis rice protein. None of these products is sold under an American Nutrition brand, but are sold through other independent companies. No American Nutrition brands or other products they manufacture for other businesses are affected by this recall.

    Why would I trust the word of anyone who’s accused of adding ingredients off the label? This story gets curiouser and curiouser, and it is pretty clear that between the “side dealers” in China and some greedy middlemen suppliers here, we have plenty of blame to go around.

    Stay tuned for more…

  • | |

    Circumcision and AIDS – Revisited

    condom.jpg

    A post I wrote quite a while back on circumcision and AIDS remains my most commented post ever. In it (if you’re too lazy to click) I said that while research indicating a reduction in HIV infection in circumcised men was promising, there were a couple of concerns. One, that this could be a distraction from the single most effective prevention measure (no, not abstinence!), condom use. And two, that in certain cultures, especially among Hindus, this would be an absolute no no because circumcision is identified with being Muslim.

    Anyway, in a review article, the Cochrane Centre in South Africa summarizes results from a meta analysis of a number of trials indicating a 50% reduction in HIV incidence among circumcised males. At this point in time, it is clear that circumcision is effective in reducing HIV incidence among heterosexual males. Based on this, the institute encourages the widespread use of circumcision as an AIDS prevention strategy.

    So, am I still circumspect? Absolutely. I am still concerned that this research will be misinterpreted in a way that discourages condom use. In fact, the authors note that circumcised men indulged in more risky behaviour. Also, the incidence of HIV in the women these men were sleeping with increased from 9.6% to 13.8%, a 40% uptick. This increase was not statistically significant. No arguing with that, though the study was stopped early once it was clear that the men were helped, never mind the women, or reaching statistical significance in their case.

    Given that it is very unclear what the effects of circumcision are on anything other than circumcised penises, which are only one half of the equation (or less!), I don’t think it is responsible to call for widespread use of circumcision as a public health strategy for the prevention of HIV until its effects on the other parties are known. While people are aware of this issue, I don’t think the science or the cultural landscape promote the use of circumcision as a HIV prevention strategy until its proven that women are not at risk from increased HIV incidence either biologically from a yet unknown mechanism, or socially from increased risk taking.

    Men have more power in most societies to demand and receive sex on their terms. So the male centric nature of this research, and the conclusions drawn are disturbing. How irresponsible is it to encourage a public health strategy that appears to increase risk taking behaviour among men when the effects on the women are yet unknown, with only a statistically “insignificant” 40% increase in HIV incidence among women being observed?

    I am. for very good reason, still circumspect on circumcision.

    Whisky flavoured condoms courtesy bruno  girin’s photostream used under a creative commons license. Now how’s that for a turn on, whisky!

  • |

    Ethanol significantly worse than gasoline for air pollution

    So, Mark Jacobson from Stanford, an accomplished atmospheric chemist and modeler from Stanford, puts ethanol into his modeling mix as an automobile fuel and comes up with increased ozone, peroxyacetyl nitrate (PAN, an ozone precursor) and acetaldehyde, leading to a possible increase in mortality. Without reading his paper, I cannot comment on the assumptions used, but this is an additional issue to be concerned about as our politicians continue to binge on alcohol. It’s weird, almost as if there’s something intoxicating and addictive about this fuel :-;

    Effects of Ethanol E85 versus Gasoline Vehicles on Cancer and Mortality in the United States

    Ethanol use in vehicle fuel is increasing worldwide, but the potential cancer risk and ozone-related health consequences of a large-scale conversion from gasoline to ethanol have not been examined. Here, a nested global-through-urban air pollution/weather forecast model is combined with high-resolution future emission inventories, population data, and health effects data to examine the effect of converting from gasoline to E85 on cancer, mortality, and hospitalization in the United States as a whole and Los Angeles in particular. Under the base-case emission scenario derived, which accounted for projected improvements in gasoline and E85 vehicle emission controls, it was found that E85 (85% ethanol fuel, 15% gasoline) may increase ozone-related mortality, hospitalization, and asthma by about 9% in Los Angeles and 4% in the United States as a whole relative to 100% gasoline. Ozone increases in Los Angeles and the northeast were partially offset by decreases in the southeast. E85 also increased peroxyacetyl nitrate (PAN) in the U.S. but was estimated to cause little change in cancer risk. Due to its ozone effects, future E85 may be a greater overall public health risk than gasoline. However, because of the uncertainty in future emission regulations, it can be concluded with confidence only that E85 is unlikely to improve air quality over future gasoline vehicles. Unburned ethanol emissions from E85 may result in a global-scale source of acetaldehyde larger than that of direct emissions.

  • Autism epidemic not caused by shifts in diagnoses; environmental factors likely

    California’s sevenfold increase in autism cannot be explained by changes in doctors’ diagnoses and most likely is due to environmental exposures, University of California scientists reported. The scientists who authored the new study advocate a nationwide shift in autism research to focus on an array of potential factors in the environment that babies and fetuses are exposed to, including pesticides, viruses and chemicals in household products.

    Autism epidemic not caused by shifts in diagnoses; environmental factors likely — Environmental Health News

    One of the most common arguments you will see about a lot of mental health diagnoses is that doctors have changed their diagnostic practices significantly. While there is evidence of this occurring in diagnoses of childhood depression, anxiety, or even bipolar disorder due to the millions of dollars involved in medication and the attendant corruption, autism is different.

    This population study used 17 year data in California and concluded that diagnostic changes were only responsible for a 2 fold increase, not the seven fold increase seen. The rest is unexplained, and the authors attribute it to a confluence of environmental and genetic factors.

    And no, for the last time, VACCINES DO NOT CAUSE AUTISM!

  • |

    Al Franken is good for health

    You know what's in your food and many beauty products. Senator Al Franken wants to make it possible to see exactly what's in your household cleaning products as well.The Minnesota Democrat introduced a bill in the U.S. Senate requiring producers to fully disclose all ingredients on their product labels, including those suspected of causing long-term harm. Currently the warnings on cleansers are designed to prevent immediate harm due to swallowing, splashing in eyes or other unintended uses.

    via Kare 11

    It would seem common sense to have information on labels, especially on the harsh and powerful chemicals we use every day. You may not understand what they mean, or how to pronounce the chemical names, but you don’t have to! Organizations such as the Environmental Working Group have extensive information on common high volume chemicals so people can match what they see on the label with what they would like to avoid.

    But it is not the law of the land in the US, or Canada for that matter. Al Franken, comedian, talk show host and an intelligent man turned senator would like to change that in the US. Of course, we in Canada would benefit as well.

    Chemical manufacturers aren’t having any of this.

    There’s always a concern about turning labels into encyclopedias,” Brian Sansoni of the Soap and Detergent Association, in Washington, D.C., told KARE Tuesday.

    Pretty insulting, claiming that your consumer does not like encyclopedias, or is not capable of reading and googling.

    Information helps drive consumers to safer alternatives. If you see two cleaners, both of which claim to work equally well, a quick read of the ingredients will drive you to the safer (or simpler) choice. Clearly, sale by obfuscation is the preferred marketing strategy here.

    If I were American, I would call my senator/congressperson and ask them to support Al Franken.

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