Coal Fired Power Plants – Moratorium needed

Boy, it’s all arsenic all the time on this blog!

Chemical & Engineering News: Latest News – In Katrina’s Wake, An Arsenic Threat

An incredible 72 million m³ of debris was created when Hurricane Katrina wreaked havoc in Louisiana and Mississippi in 2005. A survey of this debris now reveals that an estimated 1,740 metric tons of arsenic could leach into groundwater from unlined landfills where the materials are being disposed (Environ. Sci. Technol., DOI: 10.1021/es0622812).

Here’s EPA’s page on arsenic treated wood, and here’s the cheerleader page for same (mmm, industry advocacy websites, delicious!). Note that the EPA is currently working with the manufacturers to “voluntarily” phase out the use of Chromated Copper Arsenate in residential settings. Note that there are several alternatives available, all of them less toxic and equally effective. While this “voluntary” action limits direct exposure for certain types of people, old wood ending up in unlined landfills will overwhelmingly affect people who live near said landfills, namely the poor, and African American. 

Even lined landfills leak eventually, and while other organic matter may degrade before the leaking, arsenic and heavy metals are not going anywhere. Unlined landfills, which is a fancy way of saying hole in the ground where you throw trash in, are completely unacceptable in this day and age in a so called developed country like the US of A. On the other hand, it is fashionable to refer to Louisiana as a third world country, so I guess anything goes for those kinds of people, eh.

Holy tentacular twins, Batman! This is crazy news, the first study linking the incidence of twins with environmental factors. The culprit is growth hormone fed to cows to increase milk production. According to this Wikipedia article, a third of all dairy cattle use Monsanto’s rBGH (or rBST) brand Posilac®, so obviously, use is widespread.

FEED – July 2006 (from the Union of Concerned Scientists)

1. Engineered hormone in milk may be linked to twinning. A recent study found that women who consumed dairy products were five times more likely to give birth to twins than vegan women. The study suggested that the use of engineered bovine growth hormone/bovine somatotropin (BGH/BST) to boost milk production in dairy cows may be related to the higher level of twinning. BGH is known to increase twinning in dairy cows. In addition, the rate of human twinning is twice as high in the United States, where BGH is used, as in Britain, where BGH is banned. BGH affects twinning rate by increasing insulin-like growth factor (IGF), a protein produced in the milk of both animals and humans, that promotes ovulation and may help early-stage embryos survive. A separate study found that levels of IGF were 13 percent lower in vegan women than in women who consumed dairy products. Read a press release about the study, which was published in The Journal of Reproductive Medicine.

If true, no woman should ever drink “conventional” milk (non-organic, non rGBH free, etc). Twins are fun, I love my twin nieces very much, but they are much more difficult to carry and deliver, and there are more complications.

Scary, but I suspect this is the tip of the iceberg as far as environmental effects on childbirth are concerned.

BlogTogether

Thanks for a kickass conference, Anton, Bora, Brian and The real Paul Jones, thanks so much for the great program and getting all these people together. Everything worked, wifi, lunch, dinner, all the projectors, all the microphones, the swag, wow! It was great to put faces to people, make connections, etc.

Technorati Tags: sciencebloggingconference

ES&T Online News: Can drugs found in water harm humans?

Researchers agree that aquatic species face the greatest risk from exposure to low levels of pharmaceuticals, such as synthetic hormones, which can act as endocrine disrupters at environmental levels. However, little is known about the potential human health effects arising from complex drug mixtures.

Well, it is often more difficult to analyze complex mixtures because Experimental Design 101 makes you want to isolate the effects. And when you do compounds one by one in series, the tendency is to always add them up from the individual experiments. Unfortunately, body chemistry is not like that. I’ve always wanted to design a study that started complex and then tried to isolate later.

To his surprise, Pomati observed that this mixture of drugs at environmental levels inhibited the growth of human embryonic kidney cells. After 48 hours of exposure, cell proliferation was reduced by 10–30% compared with controls. However, no inhibition was observed when cells were exposed to only the toxic cancer drug at environmental levels.

Well, that seems conclusive enough, but here comes the “Experimental Design 101” Scold:

The results show that the growth inhibition is not due to the single most cytotoxic compound alone. But that does not conclusively prove that synergistic or additive effects exist between drugs in the mixture, cautions Thomas Heberer of the Institute of Food Chemistry at the Technical University of Berlin. To show that the individual drugs behave additively, Heberer suggests that researchers should analyze the effects of compounds with a common mode of action, such as antibiotics, alone and in various mixtures.

No, No, and No. Doing this presupposes that you know that mechanism of action, meaning you’ve half answered your question. The question Heberer is trying to answer is “do individual drugs with the same mode of action behave additively”. The question Pomati is trying to answer is “Can we demonstrate cytotoxic effects of a cocktail of drugs at ambient levels in a laboratory setting”? These are two completely different questions and Pomati’s question is more valuable at this point in time. Heberer’s strategy, on the other hand, will keep a lab well funded for years to come! But, it is very much the final step.

It is more important at this point in time to demonstrate other effects such as endocrine disruption, mutagenicity, etc in the lab at environmentally relevant levels of mixtures. Then we can get a better handle on which  effects are relevant and which ones to ignore.