Folklore Based Medicine?

Breast cancer theory supports African folklore – CNN.com

While they stressed that women should always get screening and quick treatment for breast cancer, they said their theory could also help explain the belief, widespread in parts of Africa and the United States, that removing a tumor can hasten death. “I must say that I am sure there is more to this than just a myth,” said Michael Retsky of Children’s Hospital and Harvard Medical School in Boston, Massachusetts. His latest hypothesis, which he admits is not supported by any new direct research, is published in the International Journal of Surgery. He stressed that any woman with breast cancer should get the tumor removed. And he noted that in the United States, the women who could be considered at risk of having their cancer spread now get chemotherapy anyway, which would stop cancer’s spread.

Note, no direct evidence, no double blind trial, just a story? C’mon, you’re a Doctor. Surely, you know that CNN and the other media will take your qualifications, reservations and cautions  and shove them up your you know what to get a nice headline. Most people don’t read past the first two lines anyway, so nothing you say about your reservations will be transmitted to the public.

I hope you get the funding to prove/disprove your contention. Race based differences in treatment outcomes are not well studied, and are potentially very important. It is vital that more people look at this issue. But speculation based on modeling studies does not belong on CNN.

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    FDA cannot find anything in China

    FDA Finds Chinese Food Producers Shut Down – washingtonpost.com

    American inspectors who arrived in China last week to investigate the two companies that exported tainted pet food ingredients found that the suspect facilities had been hastily closed down and cleaned up, federal officials said yesterday.

    “There is nothing to be found. They are essentially shut down and not operating,” said Walter Batts, deputy director of the Food and Drug Administration’s office of international programs.

    Well, we gave them plenty of warning, did we not!

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    Grad student measures hazardous levels of air pollution at cigar show

    Sure makes my graduate work in air quality seem a little tame!

    The man behind the subterfuge (Researcher 2, male) was Ryan David Kennedy, 34, a scrappy Canadian graduate student with crooked glasses who is studying the impact of tobacco on air quality.He crossed the border at Buffalo on Monday morning and on Tuesday crashed the giant cigar party and trade show sponsored by the publisher of Cigar Aficionado magazine at the Marriott Marquis in Times Square.

    At a Cigar Show, an Air-Quality Scientist Under Deep, Smoky Cover – New York Times

    Well, what did he find? Particulate matter readings four times higher than “hazardous”. Sometimes I think of strapping on a sampler and going to the local bar just out of curiosity. I can leave the bar if it gets smoky, the bartenders and wait staff can’t. I don’t see why this is not a clear case of hazardous working conditions leading to an immediate indoor smoking ban.  but what do I know, I’m just a scientist!

    Happy Thanksgiving.

    Blogged with Flock

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    Circumspection on Circumcision – Lessons for India

    Circumcision May Help Protect Against HIV – washingtonpost.com

    Getting circumcised may reduce men’s risk of acquiring HIV, according to a study conducted in Africa. “Our study shows that circumcised men had 53 percent fewer HIV infections than uncircumcised men,” lead study author Robert Bailey, professor of epidemiology at the University of Illinois at Chicago (UIC), said in a prepared statement.

    This study, published in The Lancet (registration and kidney donation required!) adds to the growing body of research suggesting that circumcision significantly reduces the incidence of HIV infection. The doubts on circumcision as a protective factor against HIV are falling away.

    But, is this a viable public health strategy? In context, the US health and human services reports an 85% reduction in HIV risk through condom usage. This is probably a conservative estimate. There’s no indication yet that the gains from circumcision and condom use together are multiplicative.

    Let’s look at India, for instance. Circumcision is not practiced among Hindus. There is no history of circumcision, and when I was growing up, it was clear that circumcision was for Muslims and Muslims only. It was often laughed about and there was a sense of superiority about not having to mutilate. It was a clear distinction setting difference between “us” and “them”. This article by Jaishanker and Haldar provides some perspective on Hindu-Muslim identities.

    Apart from that, the other important identity of Muslim males is circumcision. It is found in many riots that Muslims were victimized based on their religious identity. In the riots if the perpetrators or the police are not able to identify victims with their religion they forcefully remove the pants of the victims to check whether they are circumcised or not. Once they find that the victim is circumcised he is targeted without further analysing which community he belongs to.

    For example in Bombay riot (1992) there is a case of man who was frisked by the police for assessing whether he was a Muslim. However, out of fear he gave his name as Raju (a Hindu name) the officer made him take out his trousers and, noticed that he was a circumcised Muslim, and fired at him.

    No Hindu parent in their right mind would circumcise their male child. It’s that simple. It’s part of the ingrained Hindu psyche that having an uncut member sets us apart from our Muslim brethren.

    Nothing has changed about AIDS prevention strategies. But it’s boring to study the same variables all the time, let’s recap them one more time, shall we!

    Education and awareness: Look at this picture from India (from the NFHS Survey):
    Now tell me that increasing awareness among women and empowering them is not the most important thing you can do!

    Condom use = 85% risk reduction

    Nothing more to say. Continuing to improve access to condoms is important. Avert indicates that condom use is very state dependent, especially among sex workers, with Tamil Nadu having an 80-90% use rate and Mysore in neighboring Karnataka having a 9% use rate.

    Access to antiviral therapy

    India is in a lucky position here with a very well established pharmaceutical industry. So, drugs are likely to be available (patent issues notwithstanding). The issue however is with infrastructure, getting the drugs to the right people at the right time. This 2004 paper from the Indian Journal of Medical Ethics indicates that coverage is spotty at best. India’s National AIDs Control Organization (NACO) recognizes this, but in my opinion does not go far enough to provide free/affordable drugs to infected people, especially to prevent mother-child transmission.

    So, to cut a long story short, circumcision in India is not likely to be a factor in the pantheon of choices available. We have a long way to go with our other major AIDS prevention challenges, and I hope this circumcision issue does not become an increasing distraction.

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    CMA condemns Asbestos

    The Canadian Medical Association Journal is denouncing the federal government for what it expects will be Canada's continued efforts to block international controls on asbestos at UN-sponsored negotiations next week.

    A strongly worded editorial, appearing in tomorrow's issue of the journal, says the government "knows what it is doing is shameful and wrong" and compared Ottawa's moral stature in continuing to promote the use of the cancer-causing material to that of arms traders.

    The negotiations, known as the Rotterdam Convention, are to start Oct. 27 in Rome. The focus of the talks will be on whether to add the chrysotile variety of asbestos to the world's list of most dangerous substances. Once a substance is listed, countries must give prior informed consent that they know they are buying a highly dangerous material before being allowed to accept any imports.

    via globeandmail.com: Medical journal blasts Ottawa for promoting asbestos abroad

    Canada’s national shame, its export of a killer product not used by Canadians to developing countries where the safeguards it insists on for the ‘safe” use of this product can’t possibly be carried out or enforced. For god’s sake, it’s 700 jobs, and people who can be retrained to do something that does not kill people.

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    An off patent miracle cancer cure?

    Interesting news coming out of Canada from a Dr. Anselm at the University of Alberta about a well known chemical dichloroacetic acid (like vinegar with two chlorines!).

    Cheap, safe drug kills most cancers – health – 17 January 2007 – New Scientist

    It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

    It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

    Here’s the PubMed citation for the article, filled with biology I will have no hope of understanding! I read the press release on sciencedaily a few days back and did a little background digging.

    A clinical trial conducted by Colombia University studying the effects of dichloroacetate on MELAs (stroke like symptoms) was halted early because everyone taking the medication showed significant effects of neural toxicity. This study was commented on by Dr. Anselm who theorized that the effect could be caused by a specific gene mutation not seen in a lot of the patients he works with.

    So, there is some reason for caution on this wonder drug, it may be toxic at certain doses to certain people. Most chemotherapetic drugs are horrendously toxic too. But if this is not a concern, Dr Anselm, meet Sunil Shaunak and his wonderful proposal to setup an alternative pipeline for drug approval that does not involve big/small pharma. I Am sure between Bill Gates, or George Soros, a few million bucks can be rustled up for a cancer cure.