Justices rule against Duke on pollution controls

I have written about bisphenol A recently. It’s a chemical found in polycarbonate plastics that has been linked with some crazy effects in mice at ambient levels including disruption of oogenesis (egg production) and effects two generations removed (grandmother effects).

Public health agency linked to chemical industry – Los Angeles Times

For nearly a decade, a federal agency has been responsible for assessing the dangers that chemicals pose to reproductive health. But much of the agency’s work has been conducted by a private consulting company that has close ties to the chemical industry, including manufacturers of a compound in plastics that has been linked to reproductive damage.

In 1998, the Center for the Evaluation of Risks to Human Reproduction was established within the National Institutes of Health to assess the dangers of chemicals and help determine which ones should be regulated. Sciences International, an Alexandria, Va., consulting firm that has been funded by more than 50 industrial companies, has played a key role in the center’s activities, reviewing the risks of chemicals, preparing reports, and helping select members of its scientific review panel and setting their agendas, according to government and company documents.

This kind of work is too important to be left to contractors like Sciences International (however good they may be), which also has contracts with companies that manufacture and market products containing Bisphenol A. It’s very simple, most companies, for profit entities and even non-profits dependent on funding sources tend to maximize short term gain over long term good. While the political arm of the government does that as well, the institutions stable enough to do reliable work on policy issues that affect our long term well being are few in number. Government run research with stable funding, good employees and good management will do this work well, it’s a good match between the nature of the work and the nature of the organizations.

The ever excellent Pump Handle has more, I read their post as I was writing this one and so, nothing more to say, really, except, remember Children of Men! Fertility is not to be toyed with, any chemical that has the ability to affect egg production two generations down needs to be handled with care. 

Nalgene, and other so called safe hard plastics made from polycarbonates. Read here for background and all previous Bisphenol A postings.

PLoS Genetics – Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse

In the course of studies to assess the effects of BPA on the mouse oocyte, we have uncovered a novel “grandmaternal” effect: exposure to BPA during pregnancy disturbs oocyte development in unborn female fetuses. When these fetuses reach adulthood, the perturbations are translated into an increase in chromosomally abnormal eggs and embryos. Thus, low-dose BPA exposure during pregnancy has multigenerational consequences; it increases the likelihood of chromosomally abnormal grandchildren. Our studies also provide mechanistic insight, and, surprisingly, suggest that BPA acts in the fetal ovary not by mimicking the actions of estrogen but by interfering with the function of one of the known estrogen receptors. Thus, our data suggest that estrogen plays a far earlier role in oocyte development than previously suspected and, importantly, raise the possibility that a variety of substances—both synthetic and naturally occurring—that mimic the actions of estrogen or act as estrogen antagonists may affect early oocyte development.

Once again, caution is involved in the interpretation of the results, mice are more sensitive than humans to environmental exposures. The heartening part of this, and other recent studies is that work is now being carried out at doses that are more representative of ambient exposures, making results much more relevant. The part in bold is equally interesting. Estrogen is a very powerful hormone that has so many unknown effects on the body (and the mind, presumably :-;)

But, will it make tea? File it under the “too good to be true” department. I’ll believe it when it happens.

From Wales, a box to make biofuel from car fumes: Scientific American

The world’s richest corporations and finest minds spend billions trying to solve the problem of carbon emissions, but three fishing buddies in North Wales believe they have cracked it.

They have developed a box which they say can be fixed underneath a car in place of the exhaust to trap the greenhouse gases blamed for global warming — including carbon dioxide and nitrous oxide — and emit mostly water vapor.

The captured gases can be processed to create a biofuel using genetically modified algae.

So, what they’re saying is that they have designed a device that can safely sequester most of the toxic components of automobile exhaust for a little while. Then, you take this “magic box” down to your local refinery where this sequestered gas is mixed with some algae. The algae then uses this CO2 as fuel to make biodiesel.

Very cool in concept. Kinda hard to critcize without the details, No?

I am sure everyone has heard about the wonders of nanotechnology, but what about the other side?

ScienceDaily: Tiny Inhaled Particles Take Easy Route From Nose To Brain

In a continuing effort to find out if the tiniest airborne particles pose a health risk, University of Rochester Medical Center scientists showed that when rats breathe in nano-sized materials they follow a rapid and efficient pathway from the nasal cavity to several regions of the brain, according to a study in the August issue of Environmental Health Perspectives

There was a time when asbestos was the wonder material, malleable and fire resistant, capable of being woven into sheets, and being incorporated into buildings for fire retardation. Unfortunately, many cases of asbestosis and mesothelioma later, not so wonderful. Asbestos is a special case because the fibers started out big and would keep breaking down into smaller particles till they reached that magic size range between 0.1 and 1-2 um where they could stay suspended in the air for a long time, and also take advantage of the lungs’ inability to filter particles that size to any great degree of efficiency.

Nanoparticles are an order of magnitude smaller, and hence behave more like gases. They may  also contain choice toxic heavy metals such as manganese which are not usually floating around in the air at these small sizes. So, this study is a little scary, especially for the folks in the manufacturing end of things, these miracle particles seem to be going straight to the brain. Traditional masks and air handling systems are not designed to filter such fine particles, so I am sure they’re floating around in the air waiting to be breathed in.

Update 9:00 AM, 8-3-2006
Well, I swear, I did not see this before I wrote this morning!

The question of the day, however, is are they safe for humans and other living things? Earlier this year, Andrew Seaton, A U.K. scientist who was the lead author of a 2004 report investigating the saftey of nanotechnological materials raised a bit of a ruckus by comparing carbon nanotubes to asbestos fibers. Asbestos once had its day in the sun as an all-purpose wonder material. But then we learned that tiny asbestos fibers, once ingested by the human body, could be extremely deadly. Carbon nanotubes: also easy to ingest, and exquisitely capable of penetrating cell structures. Could they be equally toxic?