|

Snake Oil Comes a Full Circle

Ah, back to the good old days of snake oil..

ScienceDaily: Snake Venom As Therapeutic Treatment Of Cancer?

This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics.

These novel findings suggest that SVT can inhibit the growth of AICAP through the induction of cell death.

I am glad they put the question mark at the end, lest people extrapolate from a few cells in a petri dish (or a small animal study) to a cancer cure, as happened recently with dichloroacetate! Health reporting is very tricky because the average reader cannot understand much more than the headline. It almost seems like every health article should have the following things clearly labeled:

  1. Human, animal or cell?
  2. Clinically tested, or anecdotal?
  3. Double blinded, controlled, etc, or not?
  4. Any chance that this result applies to people?
  5. How far away are we from a real cure?
  6. DO NOT TRY THIS AT HOME!

At least viper venom is hard to find! The Madras crocodile bank helped start a venom extraction cooperative run by the Irula Tribe, so I’ve seen viper venom being extracted, pretty cool. India is home to two vipers, the Russell’s and the Saw Scaled vipers.

Russell's
Russell’s viper

saw scaled
Saw scaled viper.

The Russell’s is 3-5 feet long, and slow, but a big hisser! The saw scaled viper is tiny, a feet or two, but aggressive and very venomous. One of my favorite wild snake sightings was a saw scaled viper, looked very innocuous curled up in a parking lot in Pondicherry.

Cool, snake oil and venom for all…

Similar Posts

  • |

    South Asians: Watch your Heart

    Seems like us South Asians die earlier from heart attacks.

    ScienceDaily: South Asians Have Higher Levels Of Heart Attack Risk Factors At Younger Ages

    Deaths related to cardiovascular disease occur 5 to 10 years earlier in South Asian countries than in Western countries, according to background information in the article. This has raised the possibility that South Asians exhibit a special susceptibility for acute myocardial infarction (AMI; heart attack) that is not explained by traditional risk factors.

    But why?

    The prevalence of protective risk factors (leisure time physical activity, regular alcohol intake, and daily intake of fruits and vegetables) were markedly lower in South Asian study participants compared with those from other countries.

    Um, it is mainly behavioral, not genetic according to the authors, and hence can be mitigated by lifestyle changes.

    Well, I guess it is time to take a personal stock as of 1-18-2007:

    • Weight – Well, I am in the lower end of the healthy BMI.
    • Exercise – 4-5 days of 45 minutes – 1 hour per day, pretty good.
    • Food – Well, mostly good, especially if the candy can be avoided. I need to eat more vegetables, but I eat a lot of high fibre, and whole wheat food, probably not enough protein, mostly vegetarian.
    • Alcohol (1-2 drinks is apparently a heart protector) – Amen, I am a religious one drink a day partaker, more on weekends :-;
    • Smoking – Well, gave that up a while back, now to quit that occasional “party” smoke.
    • Stress – Well, not so good, this is probably the area I would need to work on the most.
    • Hypertension – Well, I am borderline on my blood pressure readings 🙁 Need to work on that.
    • Cholesterol – Still waiting for results on my physical.

    On the whole, I seem to be in decent shape. It’s good to take stock once in a while.

  • Melamine movin' on up the food chain

    The FDA mentioned recently that the melamine suspected of poisoning many cats had gotten into pig feed in California, well, it gets worse…

    Tuesday: Uh-Oh — North Carolina Public Radio WUNC

    The FDA announced this afternoon that thousands of hogs in NC and four or five other states are now under quarantine because they were fed tainted rice gluten. Hogs here and in CA have tested positive for melamine. No one knows yet whether it poses any dangers to humans who ate the hogs, but the feds say they’re trying to find out.

    At this point in time, I would consider any animal feed from China suspect. Way out of control, because we have no procedure for being proactive about these things…

    It won’t amount to much because melamine apparently does not affect humans as much as it seems to affect cats, but it is the utter lack of control of ingredients and raw materials that scares me. What else can sneak through? What if the next one is actually deadly to humans?

  • |

    Glass baby bottles making comeback

    More Bisphenol A blowback, apparently, SF parents are switching to glass.

    Glass baby bottles making comeback / Stores selling out after health alarms raised about plastics

    Glass baby bottles, replaced decades ago by unbreakable plastic, are making such a comeback that parents can’t get their hands on them.

    Online and brick-and-mortar retailers report a run on glass baby bottles in recent weeks that they say was spurred by reports that the most common type of plastic in baby bottles may leach a toxic chemical.

    San Francisco resident Sean Mullins said he decided to switch his 6-month-old son, Mickey, from plastic to glass bottles last month despite manufacturers’ insistence that plastic bottles are safe.

    Independent tests done for The Chronicle and reported in November found bisphenol A, a chemical that mimics estrogen, in a baby bottle and several toys. Bisphenol A is also found in the lining of food cans, some anti-cavity sealants for teeth, and electronics.

    Watch for plastics manufacturers to fight back, this study ought to provide some ammo.

    Comparison of six samples of each of three brands of water available in both glass and polyethyelene terephthalate (PET(E)) showed that the waters bottled in glass contained approximately 57, 30, and 26 times more Pb due to leaching from the containers. Our study includes 25 brands of bottled water from Canada, and the median Pb concentration in these samples was 15.9 ng/L (n = 25), with a range from 2.1 to 268 ng/L. For comparison with the bottled waters, pristine groundwater from six artesian flows in southern Ontario, Canada, where some of the bottled waters originate, yielded a median concentration of 5.1 ng/L Pb (n = 18). In fact, all of the waters tested were well below the maximum allowable concentration established by the EU, Health Canada, and the WHO for Pb in drinking water (10000 ng/L).

    It all depends on which bolded sentence you chose to emphasize! So, glass bottles do leach some lead out, but nowhere near the amount needed to cause any effects whatsoever. I guess this is all the American Chemistry Council can come up with as a problem with glass.

    It’s irrefutable that glass can shatter, Hentges said. But there is “no scientific basis to conclude that BPA is something to be concerned about … at the extremely low levels that people might be exposed to from use of consumer products.”

    There is plenty of scientific basis to conclude that Bisphenol A has some very subtle effects at ambient doses. But science has never stopped the American Chemistry Council!

  • | |

    Lead and Crime

    leadcrime.jpg

    The next time Giuliani tries to take credit for the decrease in violence during his tenure as NYC’s mayor, send him this chart.

    The NY Times shines some light on Jessica Reyes’ excellent work linking decreased lead exposure to a drop in violent crime in the US. The decreased lead exposure, of course, was from the phase-out of leaded gasoline from the American market. BTW, Nascar still uses leaded gasoline in its cars, nice going, guys.

    The answer, according to Jessica Wolpaw Reyes, an economist at Amherst College, lies in the cleanup of a toxic chemical that affected nearly everyone in the United States for most of the last century. After moving out of an old townhouse in Boston when her first child was born in 2000, Reyes started looking into the effects of lead poisoning. She learned that even low levels of lead can cause brain damage that makes children less intelligent and, in some cases, more impulsive and aggressive (Emphasis Added).

    Lead exposure at an early age (2-3 years) is especially significant as this is an age where personality development occurs and any interference in neuron development and apoptosis (death!) can cause permanent changes in personality. This excellent review article summarizes the effects of lead on neuronal development.

    Reyes’ research mentions that while decreased lead exposure was very well correlated with violent crime (accounting for 56% of the reduction in crime), no correlation was found to property crimes (such as theft). This of course makes intuitive sense. A property crime is usually premeditated whereas violence is usually impulsive (excluding serial killers, of course). It is more likely that a budding criminal sets out to steal a car than to beat somebody to pulp. It is when the crime goes wrong that the probability of a violent crime increases. An individual with damaged impulse control is then more likely to seek a violent way out of the bad situation.

    Our society (like most) views violent crime as a moral issue, a matter of good and evil that is determined by your “character”. So, a simple chemical correlator to violent crime that can explain a majority of the commission of violent acts goes a long way in undermining this whole notion of morality and crime. Of course, there are other sociological factors at play which need to be addressed. But it is heartening to know that beyond all the complicated and recalcitrant social issues that underly crime, there’s a ubiquitously evil pollutant lurking that can be eliminated. I am guessing that this line of reasoning is not going to be very popular among the “tough on crime” types that perpetrate our political airwaves these days.

    Reference

    Reyes, Jessica Wolpaw (2007) “Environmental Policy as Social Policy? The Impact of Childhood Lead Exposure on Crime,” The B.E. Journal of Economic Analysis & Policy: Vol. 7 : Iss. 1 (Contributions), Article 51.

  • Brazil offers AIDs drug factory to Mozambique

    Brazil is positioning itself as a major manufacturer of generics, and offering to build this factory is a very good move because it will provide AIDs treatment options for Mozambique at affordable prices (well, better prices than the pharma giants would provide, at any rate). Is there expertise available in Mozambique to staff this factory and run it at the level of quality a pharmaceutical production facility needs? I don’t know the answer, but I sure hope so. Alternatively, is there any plan for Brazil to train and equip the personnel as well? It is good news, at any rate.
    Brazil offers drug factory to AIDS-ravaged Mozambique – Yahoo News

    Brazil has offered to build a $23 million pharmaceutical plant in Mozambique that will provide drugs to treat HIV/AIDS, malaria and other diseases, Mozambique’s national newspaper said on Tuesday.

    Brazil, a leading pharmaceutical manufacturer, will monitor quality and transfer technology to the proposed plant, which would produce a range of drugs, including generic antiretroviral drugs (ARVs) to fight HIV/AIDS, Noticias reported.

    The plan was presented to the Mozambique government by Brazil’s ambassador in the southern African nation.

    Mozambique, one of the poorest nations on the continent, is struggling to find the money to rebuild its dilapidated health-care system, which was neglected during a 17-year civil war that ended in 1992.

    The former Portuguese colony has been hard hit by the AIDS epidemic, with an estimated 1.6 million of its 18 million people infected with HIV. Only a fraction of those requiring ARVs are on treatment, with most of the drugs imported from India.

    The offer to build the pharmaceutical plant was first raised by Brazilian President Luiz Inacio Lula da Silva during his 2004 official visit to Mozambique. Lula said he wanted drugs from the plant to be available to other African nations as well.

    Brazil claims the use of generic anti-retrovirals has cut its AIDS mortality rate in half.

    Mozambican Health Minister Ivo Garrido said the government would decide next month whether to approve the Brazilian proposal. “We will have to study it very carefully,” he was quoted as saying by Noticias.

  • |

    ES&T Online News: E-waste recycling spews dioxins into the air

    ES&T Online News: E-waste recycling spews dioxins into the air

    When computers, televisions, music systems, and other electronic products reach the ends of their lives, they often end up in China or other developing countries as e-waste. Such waste is a serious environmental threat in these parts of the world because of the poorly regulated conditions under which the waste is dismantled. A new study published in ES&T (DOI 10.1021/es0702925) shows that Guiyu, a major e-waste recycling center in China, has the highest documented levels of atmospheric polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs) in the world.

    In e-waste recycling centers in China, discarded products are dipped into open pits of acid and heated over grills fueled with coal blocks to extract precious metals, such as gold. These processes often release toxic metals, such as lead, and organic compounds, such as dioxins. The emissions are not regulated, and occupational exposure is high because of the poor working conditions for e-waste recycling laborers.

    In March 2007, researchers at Hong Kong Baptist University showed that soil at e-waste recycling sites in China has high levels of dioxins and polybrominated diphenyl ether (PBDE) flame retardants. (Read the paper at ES&T‘s ASAP website.) More recently, another study published in ES&T showed that the workers at these sites have blood levels of the heavy PBDE, BDE–209, 50–200 times higher than those previously reported. Whereas dioxins are potentially carcinogenic for humans, PBDEs affect thyroid metabolism and brain development.

    In the current study, Ping’an Peng of the Guangzhou Institute of Geochemistry (China) and his colleagues sampled the air from Guiyu for a week in both the summer and the winter and analyzed the samples for 2,3,7,8-PCDD/Fs. The levels varied between 64.9 and 2765 picogram per cubic meter (pg/m3). The toxic equivalents (TEQ)—a value used to account for the different levels of toxicity of the individual dioxins—was 0.909–48.9 pg TEQ/m3. Given that Guiyu has no municipal or medical solid-waste incinerators, which are known to be major sources of dioxins, the authors attributed the elevated dioxin levels to e-waste recycling.

    The team also found that the dioxin concentrations in the air around Guiyu were 12–18 times higher than those in Chendian, a town 9 kilometers (km) from Guiyu, and 37–133 times higher than those in Guangzhou, which is 450 km from the e-waste site. The results suggest that dioxin pollution from e-waste recycling is spreading to nearby areas.

    When they calculated the exposure of adults to dioxins through inhalation, the researchers found that it (68.9 and 126 pg TEQ per kilogram per day in the summer and winter, respectively) was a whopping 15–56 times higher than the World Health Organization recommended maximum of 1–4 pg TEQ/kg/day.

2 Comments

  1. Thanks for the article, I have read it before. You posted the comment on a test thread that needed to be deleted. DCA has some promise, but it is no cure at this point in time, or any point in time in the near future. It is scary that people have been self medicating on the basis of a single animal study, that was, and is my only point.

Comments are closed.