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Snake Oil Comes a Full Circle

Byoliveridley

Ah, back to the good old days of snake oil..

ScienceDaily: Snake Venom As Therapeutic Treatment Of Cancer?

This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics.

These novel findings suggest that SVT can inhibit the growth of AICAP through the induction of cell death.

I am glad they put the question mark at the end, lest people extrapolate from a few cells in a petri dish (or a small animal study) to a cancer cure, as happened recently with dichloroacetate! Health reporting is very tricky because the average reader cannot understand much more than the headline. It almost seems like every health article should have the following things clearly labeled:

  1. Human, animal or cell?
  2. Clinically tested, or anecdotal?
  3. Double blinded, controlled, etc, or not?
  4. Any chance that this result applies to people?
  5. How far away are we from a real cure?
  6. DO NOT TRY THIS AT HOME!

At least viper venom is hard to find! The Madras crocodile bank helped start a venom extraction cooperative run by the Irula Tribe, so I’ve seen viper venom being extracted, pretty cool. India is home to two vipers, the Russell’s and the Saw Scaled vipers.

Russell's
Russell’s viper

saw scaled
Saw scaled viper.

The Russell’s is 3-5 feet long, and slow, but a big hisser! The saw scaled viper is tiny, a feet or two, but aggressive and very venomous. One of my favorite wild snake sightings was a saw scaled viper, looked very innocuous curled up in a parking lot in Pondicherry.

Cool, snake oil and venom for all…

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    Colonialism, Pharmaceutical style

    Byoliveridley

    Legal wrangle puts India’s generic drugs at risk – health – 29 January 2007 – New Scientist

    Tens of thousands of people being treated for AIDS will suffer if Swiss pharmaceutical company Novartis succeeds in changing India’s patent law, the humanitarian agency Medecins Sans Frontieres warned on Monday. Novartis is challenging a specific provision of India’s patent law that, if overturned, would see patents being granted far more widely, heavily restricting the availability of affordable generic medicines, MSF says.

    In 2000, antiretroviral (ARV) treatment cost was estimated at $10,000 per patient annually. But the availability of generic drugs produced mainly in India, allowed costs to plummet to about $70 per patient per year, Mwangi adds.

    You’ve got to love the friendly multinational arguing to make extra billions while people die. But I don’t think any Indian judge will overthrow Indian patent law. And there is a national interest  exemption built into most patent statutes, per the TRIPs agreements.

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    Diacetyl hits the big time

    Byoliveridley

    It’s well known that occupational exposure to various pollutants including pesticides, manufacturing raw materials, and in this case, flavoring agents, is a serious problem affecting millions of factory and farm workers all over the world.

    Which is why it is interesting when one case of a man contracting an illness possibly linked to at-home diacetyl exposure makes much more splashy news than the well documented cases of many workers dying of such exposure at work. It is unfortunate, but people working at factories and in farms are somehow expected to handle higher levels of exposure and risk. The assumption is that they are protected by agencies such as OSHA, and that they will provided with protective wear, etc. But, when the agencies drop the ball on protecting workers, it takes an “escape” of the incident into the ambient realm for the news agencies to pick it up as a headline.

    I guess the good thing now is that this diacetyl issue is blown open, and should result in reform, because alternatives are available.

    Doctor Links a Man’s Illness to a Microwave Popcorn Habit – New York Times

    A fondness for microwave buttered popcorn may have led a 53-year-old Colorado man to develop a serious lung condition that until now has been found only in people working in popcorn plants.

    Lung specialists and even a top industry official say the case, the first of its kind, raises serious concerns about the safety of microwave butter-flavored popcorn.

    “We’ve all been working on the workplace safety side of this, but the potential for consumer exposure is very concerning,” said John B. Hallagan, general counsel for the Flavor and Extract Manufacturers Association of the United States, a trade association of companies that make butter flavorings for popcorn producers. “Are there other cases out there? There could be.”

    A spokeswoman for the Food and Drug Administration said that the agency was considering the case as part of a review of the safety of diacetyl, which adds the buttery taste to many microwave popcorns, including Orville Redenbacher and Act II.

    Meanwhile, ConAgra, the biggest manufacturer of popcorn, announces plans to drop diacetyl at some undetermined “later date”. Weird, their website’s currently down!

  • |

    Melamine – now in Pigs

    Byoliveridley

    The pet food recall gets scarier. The FDA does not have this issue under control. It is not a conspiracy to hide anything, it’s just the pace at which the FDA operates, and its lack of mandate to really regulate animal feed.

    Pet Foods May Have Been Intentionally Poisoned

    The FDA and Agriculture Department also were investigating whether some pet food made by one of the five companies supplied by Wilbur-Ellis was diverted for use as hog feed after it was found unsuitable for pet consumption.

    “We understand it did make it into some hog feed and we are following up on that as well,” Sundlof said.

    Later Thursday, California officials said they believe the melamine at the quarantined hog farm came from rice protein concentrate imported from China by Diamond Pet Food’s Lathrop facility, which produces products under the Natural Balance brand and sold salvage pet food to the farm for pig feed.

    “Although all animals appear healthy, we are taking this action out of an abundance of caution,” State Veterinarian Richard Breitmeyer said in a statement. “It is unknown if the chemical will be detected in meat.”

    Officials are investigating American Hog Farm’s sales records to determine who may be affected by the quarantine, said Steve Lyle, a spokesman for the California Department of Food and Agriculture. The 1,500-animal farm operates as a “custom slaughterhouse,” which means it generally does not supply meat to commercial outlets.

    “Mostly it is not so-called mainstream pork. This is an operation that sells to folks who come in and want a whole pig,” said Lyle said.

    Officials urged those who purchased pigs from American Hog Farm since April 3 to not consume the

    Well, the issue is not the safety of the melamine contaminated pork, the risk to humans is possibly low. The problem is that these ingredients are out of control, and unaccounted for, and being diverted to places they should not be. The systemic flaws are many, and I hope the FDA will issue some new guidelines to tighten up animal feed standards.

    Another tidbit:

    FDA officials would not release the names of the other two manufacturers that Wilbur-Ellis supplied, citing its ongoing investigation

    Is it just me, or does this always happen on a Friday???

  • |

    FDA decides to breed super bugs

    Byoliveridley

    Well, what else can you say about it. This is insanely moronic. Read this sierra club release about the overuse of antibiotics brought on by the overcrowding of animals in food production factories (aka “farms”). Read the whole article and see how much everyone will be endangered so that Intervet, Inc. can make money.

    FDA Rules Override Warnings About Drug – washingtonpost.com

    The government is on track to approve a new antibiotic to treat a pneumonia-like disease in cattle, despite warnings from health groups and a majority of the agency’s own expert advisers that the decision will be dangerous for people. The drug, called cefquinome, belongs to a class of highly potent antibiotics that are among medicine’s last defenses against several serious human infections. No drug from that class has been approved in the United States for use in animals.

    Note, a powerful and potent antibiotic that works well, but is not used much because it’s the last line of defense. But the drug company that manufactures this product cares little about long term efficacy. Their only goal is to maximize short term shareholder value. I don’t blame them, I blame the government for not doing its job, that is, to balance these short term and long term goals and protect the people that pay them a lot of money for this protection.

    The wording of “Guidance for Industry #152” was crafted within the FDA after a long struggle. In the end, the agency adopted language that, for drugs like cefquinome, is more deferential to pharmaceutical companies than is recommended by the World Health Organization.

    Cefquinome’s seemingly inexorable march to market shows how a few words in an obscure regulatory document can sway the government’s approach to protecting public health.

    There’s a reason this present U.S government works in secrecy, so these “obscure” (I am sorry, but nothing that directly affects human health can be called obscure) rule changes will not hit the public eye before it’s too late. Apparently, the FDA can now only consider resistance to food borne diseases in considering an application. That’s like saying that a hospital will only treat victims of food borne diseases, so if you catch the cold, we won’t treat you! This is the Food and Drug Adminstration (all food and all drugs), not the food borne disease protection council.

    This drug is absolutely unnecessary for the following reasons:

    1. The disease it treats (respiratory distress in cows) is brought about by insane levels of animal overcrowding
    2. There are currently a dozen antibiotics for this particular problem, none of which are considered susceptible to resistance
    3. The FDA has previous history with similar public health threats with fluoroquinolones
    4. This drug is considered a last resort drug for antibiotic resistant strains of diseases in cancer patients – So strains resistant to this drug will evolve shortly after the antibiotic is overexposed . This is a death sentence for a lot of very vulnerable people.
    5. A similar drug used in Europe for the last 10 years has resulted in an increase in resistant strains of bacteria.

    This is what you get when you vote for an ideology that hates government. You get a government that hates itself and is busy pawning parts of itself off to its cronies.

  • | |

    Arsenic in the News

    Byoliveridley

    Professor wins $1M for arsenic filter – Yahoo! News

    The National Academy of Engineering announced Thursday that the 2007 Grainger Challenge Prize for Sustainability would go to Abul Hussam, a chemistry professor at George Mason University in Fairfax. Hussam’s invention is already in use today, preventing serious health problems in residents of the professor’s native Bangladesh.

    This British Geological Survey website provides a good primer to the problem. Some key points:

    1. Arsenic is very toxic
    2. Arsenic is naturally occurring in the shallow groundwater aquifers of Bengal and Bangladesh at a toxic level
    3. The surface water is contaminated with bacteria and was responsible for high infant mortality, so aid agencies in the ’70s encouraged the use of tube wells and other groundwater pumps. While this contributed to a decline in infant mortality from gastrointestinal infections, it also dosed unsuspecting people with disease causing levels of arsenic
    4. The technology for removal of arsenic is very well known. But most solutions require electricity/periodic maintenance/technical skills and are thus not universal or sustainable.
    5. Simplicity is the key. You can’t tell the people to not drink the water, it is the only clean water available. You can’t install water treatment plants, there is no running water, you can’t rely on solutions that are centralized.

    So with all that in mind, here’s what Prof. Hussam did:

    The Gold Award-winning SONO filter is a point-of-use method for removing arsenic from drinking water.  A top bucket is filled with locally available coarse river sand and a composite iron matrix (CIM).  The sand filters coarse particles and imparts mechanical stability, while the CIM removes inorganic arsenic.  The water then flows into a second bucket where it again filters through coarse river sand, then wood charcoal to remove organics, and finally through fine river sand and wet brick chips to remove fine particles and stabilize water flow.  The SONO filter is now manufactured and used in Bangladesh. That’s great, and easy!

    That’s pretty much freshman chemistry right there, further proof that most innovation does not need new science, only people willing to spend some time on problems that don’t necessarily get looked at.

  • | | |

    The real terrorist: Pollution

    Byoliveridley

    It is true. A staggering number of people die every year due to lack of access to clean water, air or food. Aggregate statistics like these are a good way to summarize the humongous nature of the problem. While reams and reams of coverage and attention are focused on “terrorists”, people all around the world die of much more mundane causes such as bacteria in water, smog, poverty, starvation, malnourishment, etc.

    ScienceDaily: Pollution Causes 40 Percent Of Deaths Worldwide, Study Finds

    About 40 percent of deaths worldwide are caused by water, air and soil pollution, concludes a Cornell researcher. Such environmental degradation, coupled with the growth in world population, are major causes behind the rapid increase in human diseases, which the World Health Organization has recently reported. Both factors contribute to the malnourishment and disease susceptibility of 3.7 billion people, he says.

2 Comments

  2. Thanks for the article, I have read it before. You posted the comment on a test thread that needed to be deleted. DCA has some promise, but it is no cure at this point in time, or any point in time in the near future. It is scary that people have been self medicating on the basis of a single animal study, that was, and is my only point.

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