Well, all sugar is not bad for you. Apparently, when given to you in pill form by someone wearing a white coat with a pleasant demeanour, it can cure all kinds of ills.
It’s not that the old meds are getting weaker, drug developers say. It's as if the placebo effect is somehow getting stronger.The fact that an increasing number of medications are unable to beat sugar pills has thrown the industry into crisis. The stakes could hardly be higher. In today's economy, the fate of a long-established company can hang on the outcome of a handful of tests.
Via Wired
An interesting article that takes the reader through a recent history of placebos, why they seem to work better now than they used to, and tangentially, why the competitive research paradigm of the pharmaceutical industry delayed recognition, and continues to delay possible fixes and therapies.
A few things about the placebo effect:
- There appears to be a physiological and neurological basis to the effect, something that can actually be turned off by deactivating the body’s natural production of opioids.
- This effect is triggered by various patient stimuli, including exposure to advertising, faith in the medicine, doctor bedside manner, etc. It appears that for minor ailments, these effects could be as strong as the medication prescribed.
- It is not short lived, the effects can linger well after consumption of sugar pills.
- Despite all this, the article states that we are no closer to finding the most appropriate way to administer placebos (Hmm, or are we? Read on!).
Pharmaceutical companies conduct hundreds of clinical trials every year. They are not required to publish them in most countries, so negative results, failures, etc. which reflect badly on the company’s stock price are routinely hushed up. This means that the mounds of data that show tested drugs as no better than placebo are not accessible for research. This is one of the greatest drawbacks of competitive research paradigms, the lack of cooperation, the inefficiency that comes from duplication of negative results, and the lack of statistical power that comes from inability to use all the data available. In a milieu where knowledge = stock price, this is the logical approach, but something to note next time an Ayn Rand acolyte comes bleating to you about the beauty and perfection of the market. You might ask “What are some options to the current patent exclusivity driven regime”? My favourite economist Dean Baker of the Center for Economics and Policy Research has written extensively about the drug development process and alternatives in his excellent (and free to download) book The Conservative Nanny State, I suggest reading at least the chapter on drug development and patents!
Anyway, back to placebos, what to do? How to administer sugar pills in a quasi-official setting for minor ailments. It’s almost like you need a parallel paradigm of medicine that dispenses sugar pills that did not have to go through double blind randomised clinical trials. it would help if this paradigm uses vaguely scientific terminology while doing very little harm. It would work in conjunction with the conventional approach, not in competition so there is little danger of people taking sugar pills for malaria!
I give you, Homeopathy!!! This blog(ger) is no stranger to this wonderful form of medicine, involving concepts such as the memory of water, similars, dilution, etc. When I wrote about homeopathy last year, it was more in relation to the psychological aspects of my experience with it. I (and I assume you did not click through to read!) wrote about my parents’ great and enduring relationship with their homeopath, and the benefits it brought them. Back in India this time around, it was suggested that I take some homeopathy for a cold I was developing, which I did (yum, sugar!). The cold went away in a few days 🙂 There was some swine flu medicine being passed around as well (I did not partake), which worked too, nobody at home got swine flu 🙂
So, how to make it work? It already works in India because belief in the efficacy of homeopathy is well established. As long as the homeopath is well qualified in basic diagnosis, and crucially, knows when to punt the patient into conventional therapy, the system works to a certain extent. But what about a society with no such foundation? Do you go to a clinic with both an allopath and a homeopath, and if your ailment is one where placebo works about as well, let the homeopath make some well diluted similars for you to consume? How to settle turf wars? Would it be better for the allopath to feign develop an expertise in homeopathy and make that work for her in treating the patient? Would they apply the most important lessons in homeopathic treatment, Listen, Empathise, Soothe?
I don’t know. It is not my nature to believe in sugar pills, faith, or advertising. So it is hard for me to say what would work. But given that sugar pills work well, it is vital for society to find a way.
I agree with you that there is no sense in blaming China for U.S. short sightedness.
If Americans need someone to blame, then I suggest a look in the mirror.
That said, as a small farmer I must disagree with your assertion that the US need a lesson from the EU.
The EU is a disaster.
I’m of the opinion that past and current regulations and legislation has made food not just less safe, but positively dangerous.
Any more power to the USDA or the FDA could be catastrophic.
For the past 65 years or so, legislation and over regulation has fostered the fracture, industrialization and centralization of the US food supply, with all of the attending evils.
Legislation has helped to empower Archer Daniels Midland, Cargill, Con Agra, Tyson, Monsanto and et. al. , and has made them the darlings of Capital Hill.
I think America would be better served to heed the admonitions of Alexander Hamilton, George Washington and Thomas Jefferson.
Any criticism of the WTO and global economics has been dismissed as backwards protectionism.
Most Americans are disconnected to their food and haven’t a clue where it comes from.
NAFTA and other trade fiascos have encouraged the importation of cheap food from the third world, and I find it instructive, that people will readily buy and consume food grown in a country that they would not dream to drink the water if they were there on vacation.
Americans need to take more responsibility for the nation’s food crisis and begin to help themselves out of the grave they have been digging.
I produce most of my own food and realize that that is not practical for most people.
However many people can plant a small garden or at least a tomato plant. The Consumer can demand Country Of Origin labels everywhere, so as to make informed choices and buy local when ever possible.
A return to America’s original agrarianism and self reliance will not only keep us as a People safer (not just food), but the entire World will be a safer place.
Thanks for the long comment, a lot of what you say makes sense. I am curious, though, why is the EU a disaster? They have a pretty comprehensive testing program, or at least are trying to set one up. Sometimes, they go too far, and test for toxics at extremely low levels. I’ve worked on dioxin/PCB testing for EU compliance at sub-ppt levels.
It would be great to get a small farmer’s perspective on the EU program 🙂
I’ll keep my post short & brief this time.
Food Safety is more than about testing.
That’s like saying a healthy person is their lipid profile or EKG.
It would take me hours to go through and list EU general principles of food law and agriculture, and the ways in which they would destroy the last vestige of small family farms.
Small family farms are in my opinion the only last best hope this country has for safe food.
Compared to the rest of the World, the US has a different view of property rights – civil rights in general.
Many of the mandates of the EU would violate those basic Rights.
I’m thinking the 1st, 4th & 5th Amendments in particular.
The recent outcry from farmers regarding the USDA National Animal Identification System is just the tip of a very deep iceberg.
In fact I would say that NAIS will be the Titanic of the USDA, but that is a whole other story.
Here’s a quick brief 3 item list of everyday practices that come to mind.
This is just for animals, – the fruits & vegetables would be a very long list indeed.
At present, as a Citizen of the United States and as resident of the Commonwealth of Pennsylvania,
I have direct control over my animals.
That means all veterinary management care & decisions, all feed and breeding decisions.
I am free to sell you a lamb, pig, cow, chicken, duck…whatever…. direct, and if you so choose, you may slaughter that lamb in my front yard.
I am free to buy and sell raw milk.
This is not true for all of the US and certainly not an EU practice.
I’m glad the word is finally get out about China, but the problem is bigger than China.
When is somebody going to do a story about the beef that has been imported into the US from South America?
All the BSE feed that could not be sold in Europe was sold to South America.
Last I heard a few years ago, Costa Rica had bought tons of it.
Costa Rican beef has imported into the US and ended up in fast food “restaurants”.
It’s not about “testing” it’s more about greed.
Good Luck to you