Melamine – And Cyanuric Acid, A deadly pair?

Like melamine, cyanuric acid is also used to artificially increase the nitrogen content of the food (detected as protein in protein tests).

ScienceDaily: Pet Food Recall: How Melamine Impairs Kidney Function

Perry Martos and colleagues in the Agriculture and Food Laboratory at Guelph’s Laboratory Services have found that melamine and cyanuric acid can react with one another to form crystals that may impair kidney function. Tests conducted at the University’s Animal Health Laboratory (AHL) and elsewhere have identified these crystal-like substances in the kidneys and urine of affected animals. The experiments conducted at the Agriculture and Food Laboratory showed that the chemical composition of the crystals that are formed when these two compounds interact matches the composition of urinary crystals removed from affected animals. Tests conducted at the University’s Laboratory and in the United States have identified the compounds as contaminants in gluten used to make a variety of pet food and treat products.

Interestingly enough, the analytical test for cyanuric acid is to precipitate it with Melamine, so it is not as if these guys “discovered” this reaction, as the press release seems to intimate. There is also speculation that the  cyanuric acid was a metabolic byproduct of melamine from bacterial action, which is possible if the gluten was not stored correctly. It seems to me that Chinese manufacturers were using melamine or cyanuric acid to boost protein content for a while now. But it may have been only recently that they started adding both to the same food. The other possibility (and have you ever read the ingredients list in pet food, it takes a while!), is that one ingredient contained melamine, the other, cyanuric acid and when mixed…

Either way, neither of these compounds belong in pet food.

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    Circumspection on Circumcision – Lessons for India

    Circumcision May Help Protect Against HIV – washingtonpost.com

    Getting circumcised may reduce men’s risk of acquiring HIV, according to a study conducted in Africa. “Our study shows that circumcised men had 53 percent fewer HIV infections than uncircumcised men,” lead study author Robert Bailey, professor of epidemiology at the University of Illinois at Chicago (UIC), said in a prepared statement.

    This study, published in The Lancet (registration and kidney donation required!) adds to the growing body of research suggesting that circumcision significantly reduces the incidence of HIV infection. The doubts on circumcision as a protective factor against HIV are falling away.

    But, is this a viable public health strategy? In context, the US health and human services reports an 85% reduction in HIV risk through condom usage. This is probably a conservative estimate. There’s no indication yet that the gains from circumcision and condom use together are multiplicative.

    Let’s look at India, for instance. Circumcision is not practiced among Hindus. There is no history of circumcision, and when I was growing up, it was clear that circumcision was for Muslims and Muslims only. It was often laughed about and there was a sense of superiority about not having to mutilate. It was a clear distinction setting difference between “us” and “them”. This article by Jaishanker and Haldar provides some perspective on Hindu-Muslim identities.

    Apart from that, the other important identity of Muslim males is circumcision. It is found in many riots that Muslims were victimized based on their religious identity. In the riots if the perpetrators or the police are not able to identify victims with their religion they forcefully remove the pants of the victims to check whether they are circumcised or not. Once they find that the victim is circumcised he is targeted without further analysing which community he belongs to.

    For example in Bombay riot (1992) there is a case of man who was frisked by the police for assessing whether he was a Muslim. However, out of fear he gave his name as Raju (a Hindu name) the officer made him take out his trousers and, noticed that he was a circumcised Muslim, and fired at him.

    No Hindu parent in their right mind would circumcise their male child. It’s that simple. It’s part of the ingrained Hindu psyche that having an uncut member sets us apart from our Muslim brethren.

    Nothing has changed about AIDS prevention strategies. But it’s boring to study the same variables all the time, let’s recap them one more time, shall we!

    Education and awareness: Look at this picture from India (from the NFHS Survey):
    Now tell me that increasing awareness among women and empowering them is not the most important thing you can do!

    Condom use = 85% risk reduction

    Nothing more to say. Continuing to improve access to condoms is important. Avert indicates that condom use is very state dependent, especially among sex workers, with Tamil Nadu having an 80-90% use rate and Mysore in neighboring Karnataka having a 9% use rate.

    Access to antiviral therapy

    India is in a lucky position here with a very well established pharmaceutical industry. So, drugs are likely to be available (patent issues notwithstanding). The issue however is with infrastructure, getting the drugs to the right people at the right time. This 2004 paper from the Indian Journal of Medical Ethics indicates that coverage is spotty at best. India’s National AIDs Control Organization (NACO) recognizes this, but in my opinion does not go far enough to provide free/affordable drugs to infected people, especially to prevent mother-child transmission.

    So, to cut a long story short, circumcision in India is not likely to be a factor in the pantheon of choices available. We have a long way to go with our other major AIDS prevention challenges, and I hope this circumcision issue does not become an increasing distraction.

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    Snake Oil Comes a Full Circle

    Ah, back to the good old days of snake oil..

    ScienceDaily: Snake Venom As Therapeutic Treatment Of Cancer?

    This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics.

    These novel findings suggest that SVT can inhibit the growth of AICAP through the induction of cell death.

    I am glad they put the question mark at the end, lest people extrapolate from a few cells in a petri dish (or a small animal study) to a cancer cure, as happened recently with dichloroacetate! Health reporting is very tricky because the average reader cannot understand much more than the headline. It almost seems like every health article should have the following things clearly labeled:

    1. Human, animal or cell?
    2. Clinically tested, or anecdotal?
    3. Double blinded, controlled, etc, or not?
    4. Any chance that this result applies to people?
    5. How far away are we from a real cure?
    6. DO NOT TRY THIS AT HOME!

    At least viper venom is hard to find! The Madras crocodile bank helped start a venom extraction cooperative run by the Irula Tribe, so I’ve seen viper venom being extracted, pretty cool. India is home to two vipers, the Russell’s and the Saw Scaled vipers.

    Russell's
    Russell’s viper

    saw scaled
    Saw scaled viper.

    The Russell’s is 3-5 feet long, and slow, but a big hisser! The saw scaled viper is tiny, a feet or two, but aggressive and very venomous. One of my favorite wild snake sightings was a saw scaled viper, looked very innocuous curled up in a parking lot in Pondicherry.

    Cool, snake oil and venom for all…

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    India drastically reduces AIDs incidence

    India’s efforts at combating AIDs through the use of superior statistics and survey techniques (yes, we are geeky like that only!) pays off as the number of AIDs cases is slashed from 5.7 million to close to 3 million.

    Study: Fewer Indians with HIV seen – Yahoo News

    The number of Indians infected with HIV is far smaller than previously believed, according to new data that appears to vindicate critics who said earlier U.N. assessments of the country’s epidemic were vastly overestimated.

    Experts say the still-unreleased survey is likely to show that India’s number of HIV cases, which last year was said to be the highest in the world at 5.7 million, is actually well below that mark.

    “The actual number we’ve come up with in aggregate is likely to be lower, and perhaps substantially lower,” said Ashok Alexander, director of the Avahan, the Indian program of the Bill & Melinda Gates Foundation, which helped fund the study.

    Now, if we can only make the other 3 million cases go away. Unfortunately, math is not going to get us there. But this is good news, I guess, for the 2.7 million people who we thought had AIDs, but actually did not. Were these poor people clued in?

    The real reason this is good news is that if money was budgeted to take care of 5.7 million cases, then it will go a little further now! Happy Friday, takes away from all the other crap going on in my world that I am too jaded and cynical to blog about.

  • NC Smoking bill dead this year

    The vote was 55-61, and one of the arguments advanced was by Representative Paul Stam (h/t N&O’s new political blog):

    This is pushing smoke out of places where only adults are, but into places where children are. A person who’s addicted to tobacco and can’t smoke all day will get in that car and have to light up three or four or go home and do what they didn’t do during the day. That seems common sense to me.”

    Yeah, and if you stop a murderer from killing in public, he will kill at home, so we should just let him shoot people randomly in public.

    North Carolina General Assembly – House Bill 259 Information/History (2007-2008 Session)

    Whatever, it does not matter, smoking in public will be history even in the South in a decade or less, just a few lawsuits away. I think we first need to overturn the laws against local government passing anti smoking legislation.

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    Men – An Endangered Species due to Endocrine Disruptors.

    Why, it’s a girl, how surprising!!

    Man-made chemicals blamed as many more girls than boys are born in Arctic | The Guardian | Guardian Unlimited

    Twice as many girls as boys are being born in some Arctic villages because of high levels of man-made chemicals in the blood of pregnant women, according to scientists from the Arctic Monitoring and Assessment Programme (Amap).
    The scientists, who say the findings could explain the recent excess of girl babies across much of the northern hemisphere, are widening their investigation across the most acutely affected communities in Russia, Greenland and Canada to try to discover the size of the imbalance in Inuit communities of the far north.

    In the communities of Greenland and eastern Russia monitored so far, the ratio was found to be two girls to one boy. In one village in Greenland only girls have been born.

    Why are the upper latitudes especially vulnerable? Two reasons, firstly, atmospheric currents carry pollutants from the Mid-Latitudes (i.e the US, China and Europe) to the higher latitudes of the Arctic. Secondly, the pollutants they measured, PCBs, are persistent and stable (which is why they were used in the first place) and accumulate in the fat tissue of animals. So, predator fish on top of the food chain (the large oily ones) tend to accumulate a lot of these compounds. When you live in the Arctic, you tend to eat a lot of fish. So, these people are getting slammed.

    I tell you, Children of Men is not as far fetched as it sounds! Though I think the high levels these people accumulated in their system may not be representative of the rest of the world (vegetarian diets, for instance would be lower in persistent pollutants unless you consumed a ton of milk products), it is still a very scary story.

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    Canada loves asbestos (in third world lungs)

    In a normal world, when something is severely restricted in your country, you would not export it to another country under the pretense that used under certain, very restricted conditions, your product only causes a moderate increase in cancer.

    While the federal government projects an image of being a helpful, international Boy Scout on issues ranging from peacekeeping to nuclear proliferation, Canada has a peculiar relationship to asbestos.

    globeandmail.com: Asbestos shame

    But we don’t live in a normal world, because asbestos is exported from Canada to India where it is added to cement.

    Tushar Joshi, a noted New Delhi occupational health expert, is flabbergasted over asbestos sales by a country of Canada’s stature. “As a developed country, you expect more civilized behaviour,” Dr. Joshi says. Canada’s activities are “beyond comprehension,” he adds, calling Ottawa’s promotion of asbestos “a black spot on a sparkling white dress.”

    yes, well said. It is very mysterious that asbestos use in India went up in the 1980s just as evidence about its incredibly destructive effects on respiratory systems had curtailed use in most of the first world. Clearly, third world lungs are not as important as Canadian lungs.

    Asbestos is one area where Canada lags even behind the US. And Canada’s environmental practices are going to come under increasing scrutiny as climate change unfreezes the great white North and exposes the resources underneath.

    Canada, the world is watching.

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3 Comments

  1. It seems that the FDA is only centering on melamine. But, what about the origins of the cyanuric acid? What ingredients was that used in? Who supplied those ingredients? Why is there no concern about this ingredient?

    And what about the aminopterin that was found by NY state health officials? That seems to have been forgotten too.

    Elisa Law

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