All eyes on China

First it was the melamine. Then this weekend, there was that horrible story about deaths in Panama linked to the use of diethylene glycol in cough syrup. Now, pigs are dying mysteriously.

Epidemic Is Killing Pigs in Southeastern China – New York Times

Hong Kong television broadcasts and newspapers were full of lurid accounts today of pigs staggering around with blood pouring from their bodies in Gaoyao and neighboring Yunfu, both in Guangdong Province. The Apple Daily newspaper said that as many as 80 percent of the pigs in the area had died, that panicky farmers were selling ailing animals at deep discounts and that pig carcasses were floating in a river.

Lovely. China has exploded out of the gate with its development and incredible growth. But its infrastructure, bureaucracy, attitudes, government accountability and transparency are obviously way behind. The whole world faces the consequences of this lag. But my guess is that it is the rural Chinese and the ones who have been “left behind” that suffer the most, something to keep in mind I guess as people rush to blame China for yet another safety issue. We have the option of being more careful, the rural Chinese don’t.

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    Lead from toys not the real problem

    Here’s what happens when you make a long verbal rant to someone about how the risk of lead exposure from water and air probably exceeds the risk from toys with lead paint, and then don’t blog about it because that means doing an hour or two of research and you don’t find the time… Someone else has the same notion, and actually writes about it AND gets published in a mainstream website!

    The lingering danger to children from lead. – By Darshak Sanghavi – Slate Magazine

    While tainted toys are in the news now, kids historically have gotten lead from two sources: the atmosphere and house paint. Roughly a quarter-million tons of lead compounds entered the atmosphere annually beginning in 1922, after a General Motors scientist developed a lead-based gasoline additive that prevented auto knocking. Lead’s chemical durability, recognized centuries ago, also made it an attractive paint additive. Toddlers are particularly susceptible to eating lead paint because it has a sugary taste; ancient Romans used lead powder to sweeten wine. By 1980, more than half a million American children—4 percent of all toddlers—had quite toxic blood lead levels from these sources.

    Lead is a serious problem in the US, and the bulk of exposure is from crumbling infrastructure, the inability (or unwillingness) to fix and replace decaying lead pipes, and the still ubiquitous presence of lead paint layers in older houses.

    The article doesn’t still give you exposure comparisons or numbers, so I guess I still have to do the work.

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    Lasers shooting into irises

    I did not think my first minor surgery would involve someone shooting lasers to make holes in my iris. It sounds like more fun than it actually was, but was mostly painless and here I am, looking at a computer screen 3 hours later. My eyes feel like they’ve had about 5 hours of sleep, which is good considering they’re now sporting two brand new drain holes.

    Laser iridotomy is also performed prophylactically(preventively) on asymptomatic individuals with narrow angles and those with pigment dispersion. Individuals with a narrow angle are at higher risk of an acute angle closure, especially upon dilation of the eye

    http://www.surgeryencyclopedia.com/La-Pa/Laser-Iridotomy.html

    I also just started reading Bad Science by Ben Goldacre, which is about the use and misuse of the banner of science by a large group of people including nutritionists, pharmaceutical companies and “alternative” treatment specialists. It has a great chapter on the “placebo” effect, how much of it is culturally mediated, and how much doctor demeanour and confidence in their skills and outcome affects results. The doctor shooting holes in my eye was extremely confident in their skills and their results, and normally, my brain would be sending off all kinds of hubris warnings. In this case, their confidence reassured me a bit, and Bad Science definitely helped. It was also interesting to see a large section on homeopathy in the book, since I’ve written about my contact with homeopathy and felt that the cultural practices of a good homeopath can be of some use to people as long as they don’t go too far. The book confirmed some of that.

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    Glass baby bottles making comeback

    More Bisphenol A blowback, apparently, SF parents are switching to glass.

    Glass baby bottles making comeback / Stores selling out after health alarms raised about plastics

    Glass baby bottles, replaced decades ago by unbreakable plastic, are making such a comeback that parents can’t get their hands on them.

    Online and brick-and-mortar retailers report a run on glass baby bottles in recent weeks that they say was spurred by reports that the most common type of plastic in baby bottles may leach a toxic chemical.

    San Francisco resident Sean Mullins said he decided to switch his 6-month-old son, Mickey, from plastic to glass bottles last month despite manufacturers’ insistence that plastic bottles are safe.

    Independent tests done for The Chronicle and reported in November found bisphenol A, a chemical that mimics estrogen, in a baby bottle and several toys. Bisphenol A is also found in the lining of food cans, some anti-cavity sealants for teeth, and electronics.

    Watch for plastics manufacturers to fight back, this study ought to provide some ammo.

    Comparison of six samples of each of three brands of water available in both glass and polyethyelene terephthalate (PET(E)) showed that the waters bottled in glass contained approximately 57, 30, and 26 times more Pb due to leaching from the containers. Our study includes 25 brands of bottled water from Canada, and the median Pb concentration in these samples was 15.9 ng/L (n = 25), with a range from 2.1 to 268 ng/L. For comparison with the bottled waters, pristine groundwater from six artesian flows in southern Ontario, Canada, where some of the bottled waters originate, yielded a median concentration of 5.1 ng/L Pb (n = 18). In fact, all of the waters tested were well below the maximum allowable concentration established by the EU, Health Canada, and the WHO for Pb in drinking water (10000 ng/L).

    It all depends on which bolded sentence you chose to emphasize! So, glass bottles do leach some lead out, but nowhere near the amount needed to cause any effects whatsoever. I guess this is all the American Chemistry Council can come up with as a problem with glass.

    It’s irrefutable that glass can shatter, Hentges said. But there is “no scientific basis to conclude that BPA is something to be concerned about … at the extremely low levels that people might be exposed to from use of consumer products.”

    There is plenty of scientific basis to conclude that Bisphenol A has some very subtle effects at ambient doses. But science has never stopped the American Chemistry Council!

  • North Carolina Smoking ban update

    Via Laura Leslie…

    Monday: Smoking Ban Update — North Carolina Public Radio WUNC

    Late-breaking news: According to Greensboro’s Mark Binker, all systems are NOT go for a vote tomorrow. It turns out proponents of the ban may have miscounted a nose or two. The bill is conspicuously absent from Tuesday’s House calendar. Too close to call? Yep. Read Mark’s update here.

    Oh well, let’s see what happens…

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    Lead and Crime

    leadcrime.jpg

    The next time Giuliani tries to take credit for the decrease in violence during his tenure as NYC’s mayor, send him this chart.

    The NY Times shines some light on Jessica Reyes’ excellent work linking decreased lead exposure to a drop in violent crime in the US. The decreased lead exposure, of course, was from the phase-out of leaded gasoline from the American market. BTW, Nascar still uses leaded gasoline in its cars, nice going, guys.

    The answer, according to Jessica Wolpaw Reyes, an economist at Amherst College, lies in the cleanup of a toxic chemical that affected nearly everyone in the United States for most of the last century. After moving out of an old townhouse in Boston when her first child was born in 2000, Reyes started looking into the effects of lead poisoning. She learned that even low levels of lead can cause brain damage that makes children less intelligent and, in some cases, more impulsive and aggressive (Emphasis Added).

    Lead exposure at an early age (2-3 years) is especially significant as this is an age where personality development occurs and any interference in neuron development and apoptosis (death!) can cause permanent changes in personality. This excellent review article summarizes the effects of lead on neuronal development.

    Reyes’ research mentions that while decreased lead exposure was very well correlated with violent crime (accounting for 56% of the reduction in crime), no correlation was found to property crimes (such as theft). This of course makes intuitive sense. A property crime is usually premeditated whereas violence is usually impulsive (excluding serial killers, of course). It is more likely that a budding criminal sets out to steal a car than to beat somebody to pulp. It is when the crime goes wrong that the probability of a violent crime increases. An individual with damaged impulse control is then more likely to seek a violent way out of the bad situation.

    Our society (like most) views violent crime as a moral issue, a matter of good and evil that is determined by your “character”. So, a simple chemical correlator to violent crime that can explain a majority of the commission of violent acts goes a long way in undermining this whole notion of morality and crime. Of course, there are other sociological factors at play which need to be addressed. But it is heartening to know that beyond all the complicated and recalcitrant social issues that underly crime, there’s a ubiquitously evil pollutant lurking that can be eliminated. I am guessing that this line of reasoning is not going to be very popular among the “tough on crime” types that perpetrate our political airwaves these days.

    Reference

    Reyes, Jessica Wolpaw (2007) “Environmental Policy as Social Policy? The Impact of Childhood Lead Exposure on Crime,” The B.E. Journal of Economic Analysis & Policy: Vol. 7 : Iss. 1 (Contributions), Article 51.

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    Common chemicals are linked to breast cancer

    The LA Times features a study arising from the Silent Spring institute.

    Common chemicals are linked to breast cancer – Los Angeles Times

    More than 200 chemicals — many found in urban air and everyday consumer products — cause breast cancer in animal tests, according to a compilation of scientific reports published today.

    Writing in a publication of the American Cancer Society, researchers concluded that reducing exposure to the compounds could prevent many women from developing the disease.

    The research team from five institutions analyzed a growing body of evidence linking environmental contaminants to breast cancer, the leading killer of U.S. women in their late 30s to early 50s.

    Experts say that family history and genes are responsible for a small percentage of breast cancer cases but that environmental or lifestyle factors such as diet are probably involved in the vast majority.

    “Overall, exposure to mammary gland carcinogens is widespread,” the researchers wrote in a special supplement to the journal Cancer. “These compounds are widely detected in human tissues and in environments, such as homes, where women spend time.”

    The scientists said data were too incomplete to estimate how many breast cancer cases might be linked to chemical exposures.

    The resources to come out of this study include two databases, one that summarizes animal mechanistic studies, and one that summarizes human epidemiological studies. It’s a good start and I hope these databases are continually expanded. The study was essentially a big lit review and data organization project.

    There are two major issues with the way carcinogenicity is studied. Firstly, animals other than humans are dosed at high levels to test for possible cancer outcomes. This leaves most researchers vulnerable to the charge that these high dose studies do not translate well to humans because the dose-response relationship at ambient levels is not well studied. So, the obvious criticism is that just because cancer endpoints were seen at high levels does not mean that the same thing will happen at low levels. This cuts both ways, though. We’re seeing with bisphenol A that low doses can cause more harm than intermediate doses. Another issue is the additivity of the interactions. Does 1 “dose” of PAH + 1 “dose” of PCB = 2 “doses” of PAH? We’re exposed to a whole host of chemicals all our lives, who knows which ones add, which ones subtract, which ones multiply, etc.

    Of course, as with most diseases, some macro variables dominate. For instance, the US has seen 8-9% decline in breast cancer incidence recently due to a decreased use of hormone replacement therapy. So, as with all diseases, taking care of some of these big ticket items is very important. One discouraging story I read today reported on a four percentage point decline in mammograms (70 to 66%) in women age 40 and older. Why? decreased access to health insurance and dropping the ball on promotion.

    The depressing fact of the matter is that the boring basics of good preventative healthcare, screening, good lifestyle and diet are the most important factors, and if we take care of these factors, we will make most health issues easier to deal with.