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Small California Study Finds Correlational Link Between Organochlorine Pesticides and Autism

Byoliveridley

That would have been my headline! It was a study of 29 women, and the results show a six-fold increase in the incidence of autism in children whose mothers were close to fields being sprayed with organochlorine pesticides. A factor of 6 is a big number, which is why they found statistical significance at such a low sample size.

Most organochlorine pesticides (the most famous being DDT) are already banned in the first world. The ones suspected here, endosulfan and dicofol are banned in quite a few countries including Belize, Singapore. Cambodia and Germany. The Stockholm convention (international treaty to identify and restrict the use of persistent organic pollutants) has identified endosulfan as a possible addition to its list of POPs.

Of course, the US has not even ratified the Stockholm convention thanks to the pesticide lobbies. So, nothing the Stockholm convention decides about endosulfan will  carry any legal weight. In this country, pesticides and most other chemicals in current use are “innocent until proven guilty”, meaning harm must be conclusively proven in a manner that will withstand court challenge. With industry sponsored research and lobbying, such a burden of proof is often insurmountable and therefore, hazardous pollutants are used in the US well beyond their sell-by dates.

Pesticide link to autism suspected – Los Angeles Times

Women who live near California farm fields sprayed with organochlorine pesticides may be more likely to give birth to children with autism, according to a study by state health officials to be published today. The rate of autism among the children of 29 women who lived near the fields was extremely high, suggesting that exposure to the insecticides in the womb might have played a role. The study is the first to report a link between pesticides and the neurological disorder, which affects one in every 150 children. But the state scientists cautioned that their finding is highly preliminary because of the small number of women and children involved and lack of evidence from other studies.

Clearly, the increase in autism incidence has many more factors linked to it than environmental chemical exposure, but this is interesting and good work. This study will doubtless be severely criticized by the pesticide lobby. After all, it’s only a correlation, no mechanism has been proposed, and the sample size is very small. But, as I mentioned before, you don’t normally see six-fold increases in disease incidences with ambient environmental exposure, so there is definitely something going on here.

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    Gaping Reminders of Aging and Crumbling Pipes – New York Times

    Byoliveridley

    Gaping Reminders of Aging and Crumbling Pipes – New York Times

    Local and state officials across the country say thousands of miles of century-old underground water and sewer lines are springing leaks, eroding and — in extreme cases — causing the ground above them to collapse. Though there is no master tally of sinkholes, there is consensus among civil engineers and water experts that things are getting worse.

    The Environmental Protection Agency has projected that unless cities invest more to repair and replace their water and sewer systems, nearly half of the water system pipes in the United States will be in poor, very poor or “life elapsed” status by 2020.

    Yes, sewers are unsexy, there’s no new fancy science involved. But water and sewer systems are the very basis of public health, and the biggest reason why Americans don’t die of sleeping sickness and dengue fever (or their subtropical equivalents) in large numbers evey year. People who want to cut taxes and limit government need to keep this in mind. There’s no money to be made out of building and maintaining sewers, it’s a dirty job and government has to do it, or else nobody will, and money is required. We produce the waste, we need to be taxed appropriately for it. It’s that simple.

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    Bye Bye, Bisphenol A

    Byoliveridley

    Canada is expected to formally declare on Saturday that the controversial chemical bisphenol A (BPA) is a hazardous substance.

    The move will make Canada the first country in the world to put the chemical on a list of toxic substances that will ban the material from being used in such products as baby bottles.

    via CTV.ca | Canada to put BPA on toxic substances list

    Good for Canada. Timing of when cans (the biggest potential source of adult exposure) will be BPA free is up in the air.

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    Smoking bans in North Carolina?

    Byoliveridley

    After this morning’s post about Tennessee, I got curious and wanted to see what we were doing in North Carolina on smoking bans. So, I looked up my very own NC General assembly homepage and used their full text bill search function (key word smoking!). Here’s what I found.

    In the State Senate

    Great! Senate Bill S635 will ban smoking in all public places indoors except in tobacco shops, designated smoking rooms in hotels and for “research”. Follow the progress of this bill using the bill’s very own rss feed!

    In the House

    Not so good, House bill H259 has been referred to committee. But it has giant loopholes for all bars and “private clubs”. It has its very own rss feed too.

    Observations

    1. It is good to see that my representatives Kinnaird (we share a yoga class on Monday nights!) and Insko are co-sponsors on the bills. But I live in that bastion of progressivism (in the South, anyways!) Chapel Hill/Carrboro, so this is pretty unsurprising!
    2. My question to the House is this: Why are bartenders, employees of bars and private clubs, and patrons of such establishments considered not worthy of protection from second hand smoke? As someone who goes out drinking often, this is where all my exposure to second hand smoke occurs.
    3. Kudos to North Carolina for designing an accessible and easily searchable bill repository complete with rss feeds, way to go!

    Once I hear back from Sen. Kinnaird on the prospects of legislation this session, I’ll be sure to post about it.

    Update: See this. The House and Senate bills have gotten a lot closer, and most of the loopholes are gone.

  • EU's REACH Program's cornucopia of toxicology data

    Byoliveridley

    The REACH program from the European Union is an incredibly far reaching (no pun intended, of course!) effort to catalog the effects of chemical compounds on human health. I came across this interesting article at Environmental Science and Technology.

    ES&T Online News: Will the EU’s REACH serve researchers’ needs?

    Europe’s new chemicals law, REACH (Registration, Evaluation, and Authorisation of Chemicals), will put about $13 billion worth of data on 30,000 substances onto a searchable database made available at no cost on the Internet. It sounds like a dream come true for researchers wanting to design new compounds free of the structures that cause human health hazards. But lack of funding for basic research and concerns about the competence of toxicity tests have dampened expectations among some scientists.

    Well, D’uh, any program that big is bound to have some problems. But the shifting of burden of proof away from the regulators to industry is a big deal and will lead to a lot of self regulation. Companies will have to prove that their chemicals are safe.

    John Warner, a synthetic organic chemist at the University of Massachusetts, says REACH will be effective at pushing companies to select safer alternatives that are already on the market. But for the many reagents and solvents that have no safe alternatives, safe molecules must be designed, and REACH is not structured to promote the design work, Warner says.

    Yes, this is an effort to regulate existing and new chemical entities, not an initiative to spur innovation. From the REACH site:

    The REACH Regulation gives greater responsibility to industry
    to manage the risks from chemicals and to provide safety information
    on the substances. Manufacturers and importers will be required
    to gather information on the properties of their substances,
    which will help them manage them safely, and to register the
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    The innovation is going to be market driven by the fear of this regulation. Maybe we will start calling it OVERREACH!

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    The real terrorist: Pollution

    Byoliveridley

    It is true. A staggering number of people die every year due to lack of access to clean water, air or food. Aggregate statistics like these are a good way to summarize the humongous nature of the problem. While reams and reams of coverage and attention are focused on “terrorists”, people all around the world die of much more mundane causes such as bacteria in water, smog, poverty, starvation, malnourishment, etc.

    ScienceDaily: Pollution Causes 40 Percent Of Deaths Worldwide, Study Finds

    About 40 percent of deaths worldwide are caused by water, air and soil pollution, concludes a Cornell researcher. Such environmental degradation, coupled with the growth in world population, are major causes behind the rapid increase in human diseases, which the World Health Organization has recently reported. Both factors contribute to the malnourishment and disease susceptibility of 3.7 billion people, he says.

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    Flame Retardants and Hyperthyroidism in Cats

    Byoliveridley

    Caveat Emptor: They found a correlation, not a causative mechanism. But Polybrominated Diphenyl Ethers (PBDEs, yum!) have structures that can mimic endocrine hormones. Because hormones signal at very low doses and continuously, our whole toxicological risk testing structure of looking for acute effects at high doses and trying to extrapolate those effects to low doses is flawed for endocrine disrupting compounds. We are finally beginning to see some new research, especially with other toxics such as Bisphenol A, which test for chronic conditions and subtle gene and hormonal signalling effects at low doses. After all, small changes in hormone regulation especially at childbirth and a young age can have very serious effects later on in life.

    Inside Bay Area – NEW: Flame retardants linked to thyroid disease in cats

    A mysterious epidemic of thyroid disease in cats may be linked to flame retardants common in carpets, foam furniture and mattresses, according to U.S. Environmental Protection Agency researchers, who suggest that scientists have underestimated the damaging health risk the chemicals pose to humans.

    The research, published Wednesday in the journal Environmental Science and Technology, does not prove these compounds, known as PBDEs, caused the rash of hyperthyroidism in the nation’s household cats over the past 30 years.

    Rather, it lays out a hypothesis, showing that cats are heavily contaminated by these compounds, which leach from household products and are found everywhere, particularly household dust. Cats, meticulous cleaners, ingest PBDE-contaminated dust daily.

    The case of fire retardants is especially difficult because they save many lives, so manufacturers can always point to that fact and resist change. The logical fallacy, however is as follows:

    1. Fire retardants save lives (therefore good)
    2. PBDEs are fire retardants
    3. Therefore, PBDEs are good!!

    The search for a safer fire retardant needs to continue, and will not happen unless the old ones are under pressure of being phased out.