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Chip Implants Linked to Animal Tumors

Thinking about implanting an RFID microchip under your skin? Don’t do it! Why would the FDA approve something that was linked to cancers in rats?

Chip Implants Linked to Animal Tumors – washingtonpost.com:

When the U.S. Food and Drug Administration approved implanting microchips in humans, the manufacturer said it would save lives, letting doctors scan the tiny transponders to access patients’ medical records almost instantly. The FDA found ‘reasonable assurance’ the device was safe, and a sub-agency even called it one of 2005’s top ‘innovative technologies.’

But neither the company nor the regulators publicly mentioned this: A series of veterinary and toxicology studies, dating to the mid-1990s, stated that chip implants had ‘induced’ malignant tumors in some lab mice and rats.

‘The transponders were the cause of the tumors,’ said Keith Johnson, a retired toxicologic pathologist, explaining in a phone interview the findings of a 1996 study he led at the Dow Chemical Co. in Midland, Mich.

Leading cancer specialists reviewed the research for The Associated Press and, while cautioning that animal test results do not necessarily apply to humans, said the findings troubled them. Some said they would not allow family members to receive implants, and all urged further research before the glass-encased transponders are widely implanted in people.

To date, about 2,000 of the so-called radio frequency identification, or RFID, devices have been implanted in humans worldwide, according to VeriChip Corp. The company, which sees a target market of 45 million Americans for its medical monitoring chips, insists the devices are safe, as does its parent company, Applied Digital Solutions, of Delray Beach, Fla.

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    Lead and Crime

    leadcrime.jpg

    The next time Giuliani tries to take credit for the decrease in violence during his tenure as NYC’s mayor, send him this chart.

    The NY Times shines some light on Jessica Reyes’ excellent work linking decreased lead exposure to a drop in violent crime in the US. The decreased lead exposure, of course, was from the phase-out of leaded gasoline from the American market. BTW, Nascar still uses leaded gasoline in its cars, nice going, guys.

    The answer, according to Jessica Wolpaw Reyes, an economist at Amherst College, lies in the cleanup of a toxic chemical that affected nearly everyone in the United States for most of the last century. After moving out of an old townhouse in Boston when her first child was born in 2000, Reyes started looking into the effects of lead poisoning. She learned that even low levels of lead can cause brain damage that makes children less intelligent and, in some cases, more impulsive and aggressive (Emphasis Added).

    Lead exposure at an early age (2-3 years) is especially significant as this is an age where personality development occurs and any interference in neuron development and apoptosis (death!) can cause permanent changes in personality. This excellent review article summarizes the effects of lead on neuronal development.

    Reyes’ research mentions that while decreased lead exposure was very well correlated with violent crime (accounting for 56% of the reduction in crime), no correlation was found to property crimes (such as theft). This of course makes intuitive sense. A property crime is usually premeditated whereas violence is usually impulsive (excluding serial killers, of course). It is more likely that a budding criminal sets out to steal a car than to beat somebody to pulp. It is when the crime goes wrong that the probability of a violent crime increases. An individual with damaged impulse control is then more likely to seek a violent way out of the bad situation.

    Our society (like most) views violent crime as a moral issue, a matter of good and evil that is determined by your “character”. So, a simple chemical correlator to violent crime that can explain a majority of the commission of violent acts goes a long way in undermining this whole notion of morality and crime. Of course, there are other sociological factors at play which need to be addressed. But it is heartening to know that beyond all the complicated and recalcitrant social issues that underly crime, there’s a ubiquitously evil pollutant lurking that can be eliminated. I am guessing that this line of reasoning is not going to be very popular among the “tough on crime” types that perpetrate our political airwaves these days.

    Reference

    Reyes, Jessica Wolpaw (2007) “Environmental Policy as Social Policy? The Impact of Childhood Lead Exposure on Crime,” The B.E. Journal of Economic Analysis & Policy: Vol. 7 : Iss. 1 (Contributions), Article 51.

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    The Pump handle and Diacetyl

    The Pump Handle looks at the response of various government agencies (notionally charged with protecting American people) to increasing information about the danger of diacetyl exposure, certainly to workers in the flavoring industry, and recently, to consumers of microwave popcorn. An excellent post, deserves wider reading!


    Popcorn Lung Coming to Your Kitchen? The FDA Doesn’t Want to Know « The Pump Handle

    The CDC, FDA, OSHA, EPA – federal agencies charged with protecting public health – each received a letter in July alerting them to the possible serious respiratory hazard to consumers who breathe in fumes from their artificially butter-flavored microwave popcorn. The warning should have resulted in some action by these agencies, but instead, they’ve done virtually nothing.

    It appears that the Bush Administration’s efforts to destroy the regulatory system are succeeding; the agencies seem unable to mount a response to information that a well-functioning regulatory system would immediately pursue. The agencies aren’t even trying to connect the dots.

    Read on. I moved to the US in 1997 and I’ve noticed a stark difference in the performance of the government agencies named here. I have no doubt that the agencies will eventually bounce back under the right circumstances, but it is disheartening how far agencies such as the EPA, once regarded as models of well run government (at least to a developing country!) have fallen.

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    California Ban on Diacetyl?

    Flavoring-Factory Illnesses Raise Inquiries – New York Times

    For a good background on flavoring-factory lung disease (formerly known as popcorn worker’s lung), check out the Pump Handle’s many posts, especially this recent one. Short primer, diacetyl is the chemical that gives popcorn its so called buttery taste (and smell, it’s fake!!). Well, there’s pretty good evidence that diacetyl causes bronchiolitis obliterans. Some symptoms…

    Bronchiolitis obliterans renders its victims unable to exert even a little energy without becoming winded or faint.

    “The airways to the lung have been eaten up,” said Barbara Materna, the chief of the occupational health branch in the California Department of Health Services. “They can’t work anymore, and they can’t walk a short distance without severe shortness of breath.”

    OSHA has been unwilling to seriously regulate diacetyl, so California, as it is wont to do, is considering banning this killer chemical.

    But in California, which has 28 flavoring plants known to use diacetyl, some legislators and government officials seem unwilling to wait. A bill to ban diacetyl in the workplace by 2010 has passed two committees in the State Assembly and could be taken up by the full body this summer. It is the first proposal of its kind in the nation. Assemblywoman Sally Lieber, the author of the bill, said she introduced it because of what she said was the slow response by the flavoring industry, which is largely self-regulating on occupational safety. “What we’ve heard is that the flavoring industry has known for years that this is potentially a problem, and they haven’t taken action,” said Ms. Lieber, a Democrat.

    I am all for California’s regulation. But as written, this law will only protect workers in California. They should also consider going one step further by restricting the use of diacetyl in food sold in California. Only then can the giant market that is California exert its influence on the diacetyl manufacturers and users.

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    Feds punt on Bisphenol A

    By studiously ignoring all the subtle hormone disruption effects of bisphenol A and concentrating on easily observable neurological effects, the CERHR essentially does the industry’s bidding.

    Some risk linked to plastic chemical – Los Angeles Times

    A federal panel of scientists concluded Wednesday that an estrogen-like compound in plastic could be posing some risk to the brain development of babies and children.

    Bisphenol A, or BPA, is found in low levels in virtually every human body. A component of polycarbonate plastic, it can leach from baby bottles and other hard plastic beverage containers, food can linings and other consumer products.

    Culminating months of scientific debate, the decision by the 12 advisors of the Center for the Evaluation of Risks to Human Reproduction — part of the National Institutes of Health — is the first official, government action related to the chemical. Their recommendation will be reviewed for a federal report that could lead to regulations restricting one of the most used chemicals.

    The scientists ranked their concerns about BPA, concluding they had “some concern” about neurological and behavioral effects in fetuses, infants and children, but “minimal” or “negligible” concern about reproductive effects. The findings put the panel roughly in the middle — between the chemical industry, which has long said there is no evidence of danger to humans, and the environmental activists and scientists who say it is probably harming people.

    For a detailed look at how bisphenol research has been corrupted by industry sponsored “focused counter research” – where the goal is to show no effects and the experiment is tiled to ensure this goal, read this excellent article in the The Public Library of Science Biology Open Source Journal. Note, because it is Open Access, you can actually read it without selling a kidney! Some highlights…

    The moment we published something on bisphenol A, the chemical industry went out and hired a number of corporate laboratories to replicate our research. What was stunning about what they did,” vom Saal says with a mix of outrage and bemused disbelief, “was they hired people who had no idea how to do the work. Each of the members of these groups came to me and said, ‘We don’t know how to do this, will you teach us?’”

    More…

    The HCRA report, commissioned before Schwartz’s tenure, concluded that “the weight of the evidence for low-dose effects is very weak” [15]. Industry groups hailed the report as a comprehensive review by independent experts and quickly disseminated its findings. Yet the “comprehensive” report reviewed just 19 of 47 studies available in April 2002, and when it was published more than two years later, three panelists asked not to be listed as authors.

    What the hell, just read the whole article, especially the bit about the Harvard Center for Risk Analysis and its well documented industry shillness.

    The key to understanding bisphenol research is to realize that it is a hormone disruptor that works at low doses. At high doses, normal toxicological testing doses that is, it floods the hormone receptors and slows down the receptor pathways. So, the usual technique of testing in rats and mice at high doses and extrapolating will not work.

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    India Rejects Obvious Patents

    Would have been my headline. Apparently, the New York Times byline writer was more concerned about a multi billion dollar company losing a small amount of money than the fact that a different ruling in this case would have made life saving drugs unaffordable for millions of people. When did American newspapers become shills for the elite?

    Setback for Novartis in India Over Drug Patent – New York Times

    Indian companies will be free to continue making less expensive generic drugs, much of which flow to the developing world, after a court rejected a challenge to the patent law on Monday.

    Aid organizations declared the ruling a victory for the “rights of patients over patents,” but the Swiss drug company Novartis, which filed the case, warned that the ruling would discourage investments in innovation and would undermine drug companies’ efforts to improve their products.

    At issue is the degree of innovation required for a drug to be regarded as truly “new”, where there is a significant enough chance for failure that the company would never develop it unless afforded monopoly rights for 10 years. A very well known tactic by drug companies is to make a slightly different formulation of an existing drug, say an extended release form of a drug which takes a little longer to dissolve, and hence is available to the body at a different time. Under US patent law, this qualifies for full patent protection on the extended release form. By now, the science of making an extended release tablet is well known, it’s just a question of formulating the drug with a different set of inactive ingredients that take longer to dissolve, or sometimes, through a differently engineered tablet. The chemistry of this change is predictable, published and not really innovative. Why should these small changes have patent protection?

    Bonus Note: Madras is my home city, so I’m glad it was decided there!

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    Ionic Air Purifiers may actually Increase Particle Concentrations

    Take that, Sharper Image, your air purifiers that you waste tons of paper sending me monthly catalogs for don’t work. The ones that use ozone react with organic compounds in the air, especially your fragrances in cleaning products, air fresheners and perfumes to make fine particles in that crucial 0.1-1 um size range that your lungs don’t clear very effectively.

    Not a big deal in the grand scheme of things, especially with other indoor pollutants. But I always thought these air purifiers were a scam, I am glad somebody actually got the NSF to fund this study and get some proof!

    Kinetic Analysis of Competition between Aerosol Particle Removal and Generation by Ionization Air Purifiers

    Kinetic Analysis of Competition between Aerosol Particle Removal and Generation by Ionization Air Purifiers

    Ahmad Alshawa, Ashley R. Russell, and Sergey A. Nizkorodov*

    Department of Chemistry, University of California, Irvine, California 92697-2025

    Abstract:

    Ionization air purifiers are increasingly used to remove aerosol particles from indoor air. However, certain ionization air purifiers also emit ozone. Reactions between the emitted ozone and unsaturated volatile organic compounds (VOC) commonly found in indoor air produce additional respirable aerosol particles in the ultrafine (This model predicts that certain widely used ionization air purifiers may actually increase the mass concentration of fine and ultrafine particulates in the presence of common unsaturated VOC, such as limonene contained in many household cleaning products. This prediction is supported by an explicit observation of ultrafine particle nucleation events caused by the addition of D-limonene to a ventilated office room equipped with a common ionization air purifier.