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    Weight Loss drug linked to suicide and anxiety?

    Byoliveridley

    Bloomberg.com: Worldwide

    Sanofi-Aventis SA’s weight-loss pill may raise the risk of suicide and suicidal thoughts, U.S. regulators said in documents that may help an expert panel decide whether the three-time delayed drug should be approved.

    The FDA noted two suicides in clinical trials of volunteers testing the drug. The panel will be asked to discuss whether it can establish a causal link between the medicine and suicidal thoughts or actions.

    Some patients who took part in clinical trials of Acomplia suffered from mood swings, anxiety and depression. Trial volunteers given the highest dose lost an average 5.3 kilograms (11.7 pounds) over a one-year period compared with a weight loss of 1.4 kilograms (3.1 pounds) among patients given a control pill. Acomplia significantly lowered the level of HbA1c, a measure of blood sugar, to within a safe range.

    So, here’s the classic case for the FDA, as discussed earlier today! Accomplia is a drug designed for weight loss, what I would call a “life management” drug. In clinical trials, which are strictly controlled, and where patients/volunteers are selected and carefully monitored, it seems to increase the incidence of suicidal thoughts, increase anxiety, mood swings and depression. The drug acts by blocking certain receptors in the brain, which should hint at other unforseen effects on the brain. The FDA has been more cautious on this drug than the European regulators, who have approved this drug.

    What would I do if I were the FDA? I would wait 2-3 years for post approval studies in Europe to catch any mental health effects. After all, out in the real world, people take drugs imperfectly. The ones who should not qualify take it any way, doctors over-prescribe to patients who would hardly need the drug, things just don’t work as well. So, the best thing for the FDA to do is, nothing! In fact, the FDA is expected to punt the decision to 2010, good job!

    Let’s put the benefits of this drug in perspective, all it did was make people lose 10 pounds more than placebo over the course of a year. This is the functional equivalent of eating 100 calories less per day for the period. Is that worth taking a pill everyday to keep that weight off and risking depression, anxiety and suicide?

  • Pesticide makes rat grandsons unattractive.

    Byoliveridley

    Yes, strained headline!

    A Toxic Hand-Me-Down — Balter 2007 (327): 1 — ScienceNOW

    Environmental contamination can cause cancer and birth defects. Of particular concern are a group of toxic chemicals called endocrine-disrupters, which interfere with reproductive hormones and may cause sterility. A new study, published online this week in the Proceedings of the National Academy of Sciences, suggests that these chemicals can change reproductive behavior as well, and that these behavioral changes can be passed on from parents to offspring. If correct, these changes could alter the course of evolution by giving natural selection new targets to act on.

    In 2005, a team led by reproductive biologist Michael Skinner of Washington State University in Pullman reported in Science that the fungicide vinclozolin, an endocrine-disrupter used to spray vineyards and other crops, causes fertility defects in the male offspring of female rats treated with the chemical. These defects are, in turn, passed down to the males of subsequent generations. The toxin did not appear to be altering gene sequences; instead, Skinner and colleagues found, vinclozolin was somehow causing other chemical groups to latch onto certain genes, changing their expression (Science, 3 June 2005, p. 1391). The phenomenon is known as epigenetic inheritance. Last year, Skinner’s group identified 15 epigenetically altered DNA sequences in the sperm of the vinclozolin-treated rats

    More signs of intergenerational effects of low levels of endocrine disruptors. I had blogged recently about Bisphenol A having intergenerational effects (where exposure to a chemical agent causes consequences for offspring and off off spring, etc).

    It’s still early, but remember Children of Men (good movie, see it).

  • British Columbia Introduces a Carbon Tax

    Byoliveridley

    Wow, I am already proud of my future destination, a carbon tax, no less. One that will start off at $10 per tonne of carbon (2.4c per litre of gasoline, or about 9c a gallon) and rise by a factor of three in a few years…

    VICTORIA – Finance Minister Carole Taylor introduced an escalating carbon tax on most fossil fuels Tuesday, one she says recycles revenues back to taxpayers and businesses and is designed to ignite an environmental social movement in British Columbia and across Canada to fight climate change.And she’s handing every British Columbian $100 in June as seed money to get them thinking green.

    The Canadian Press: BC introduces carbon tax, but off-sets increased fuel costs with tax cuts

    The carbon tax advocacy center sets the required starter tax as 10c a gallon, BTW, so this measure by BC is no joke, it’s a serious effort to rein in CO2 emissions from the province. Carbon taxes are in general regressive as they are flat taxes, so the poor pay the same as the rich, but obviously will suffer more. So, what is the BC government doing to ensure that the poor don’t suffer?

    The carbon tax revenue, estimated to hit $1.8 billion over three years, will be returned to taxpayers through personal income tax and business tax cuts, she said.The government will introduce legislation that requires it to table an annual plan that shows how the carbon tax revenue will be returned to taxpayers, Taylor said

    Good words. But Taylor needs to realize that in the absence of well designed tax offsets, the people and businesses of BC will be at a temporary competitive disadvantage. It’s tricky to be an early adopter, but I am optimistic that BC will be the better for it.

    Wonderful, now the rest of Canada (and the US) needs to follow suit. And, I look forward to blogging about Canada already, exciting!

    Thanks of course to the grist for alerting me…

    Update: An economist allays my regressivity and harm to business fears…

    Blogged with Flock

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  • Double for Nothing: Leaving the left lane empty

    Byoliveridley

    Car Space

    Apparently. my fine province is poised to bear down heavily on those most dastardly of villains, people who dare drive their motor vehicle in the left lane…

    “There will be a number of measures that we will be implementing to do a better job in getting people out of the left lane,” Stone told Kamloops’ CHNL radio last week. “You know, it already is the law, today, not to be in the left lane unless they’re passing. … [There are] a number of initiatives that we’ll be announcing soon that we hope will make a difference to get those left-lane hogs out of the way.” – See more at: http://www.timescolonist.com/news/local/jack-knox-b-c-poised-to-make-a-move-on-left-lane-hogs-1.1158661#sthash.MYd8WAan.dpuf
    “There will be a number of measures that we will be implementing to do a better job in getting people out of the left lane,” Stone told Kamloops’ CHNL radio last week. “You know, it already is the law, today, not to be in the left lane unless they’re passing. … [There are] a number of initiatives that we’ll be announcing soon that we hope will make a difference to get those left-lane hogs out of the way.” – See more at: http://www.timescolonist.com/news/local/jack-knox-b-c-poised-to-make-a-move-on-left-lane-hogs-1.1158661#sthash.MYd8WAan.dpuf

    “There will be a number of measures that we will be implementing to do a better job in getting people out of the left lane,” Stone told Kamloops’ CHNL radio last week. “You know, it already is the law, today, not to be in the left lane unless they’re passing. … [There are] a number of initiatives that we’ll be announcing soon that we hope will make a difference to get those left-lane hogs out of the way.

    Jack Knox: B.C. poised to make a move on left-lane hogs – Local – Times Colonist.

    I get it, people who drive slowly in the left lane are annoying and are a potential safety hazard. But, given that a car already needs so much more space than a bicycle, a bus full of people or pedestrians, does having a rule saying you’re only supposed to use half the road for the majority of your driving make any sense? Think about an alternative reality in which bike lanes are built for double the capacity just in case you want to pass a slower cyclist, would never happen, right?

    A minor point, but some of the aspects of our personal auto culture are egregiously wasteful, yet attract little attention because “it’s always been that way.”

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    Lead from toys not the real problem

    Byoliveridley

    Here’s what happens when you make a long verbal rant to someone about how the risk of lead exposure from water and air probably exceeds the risk from toys with lead paint, and then don’t blog about it because that means doing an hour or two of research and you don’t find the time… Someone else has the same notion, and actually writes about it AND gets published in a mainstream website!

    The lingering danger to children from lead. – By Darshak Sanghavi – Slate Magazine

    While tainted toys are in the news now, kids historically have gotten lead from two sources: the atmosphere and house paint. Roughly a quarter-million tons of lead compounds entered the atmosphere annually beginning in 1922, after a General Motors scientist developed a lead-based gasoline additive that prevented auto knocking. Lead’s chemical durability, recognized centuries ago, also made it an attractive paint additive. Toddlers are particularly susceptible to eating lead paint because it has a sugary taste; ancient Romans used lead powder to sweeten wine. By 1980, more than half a million American children—4 percent of all toddlers—had quite toxic blood lead levels from these sources.

    Lead is a serious problem in the US, and the bulk of exposure is from crumbling infrastructure, the inability (or unwillingness) to fix and replace decaying lead pipes, and the still ubiquitous presence of lead paint layers in older houses.

    The article doesn’t still give you exposure comparisons or numbers, so I guess I still have to do the work.

  • Arnold Schwarzenegger and Jodi Rell – Lead or Step Aside, EPA – washingtonpost.com

    Byoliveridley

    The gubernator (and the Rellegator?? We need a nickname for her!) do not mince words in expressing their displeasure at the federal government putting roadblocks on state efforts to combat climate change.

    Arnold
    Schwarzenegger and Jodi Rell – Lead or Step Aside, EPA – washingtonpost.com

    It’s bad enough that the federal government has yet to take the threat of global warming seriously, but it borders on malfeasance for it to block the efforts of states such as California and Connecticut that are trying to protect the public’s health and welfare.

    California, Connecticut and 10 other states are poised to enact tailpipe emissions standards — tougher than existing federal requirements — that would cut greenhouse gas emissions from cars, light trucks and sport-utility vehicles by 392 million metric tons by the year 2020, the equivalent to taking 74 million of today’s cars off the road for an entire year.

    Yet for the past 16 months, the Environmental Protection Agency has refused to give us permission to do so.

    Even after the Supreme Court ruled in our favor last month, the federal government continues to stand in our way.

    Another discouraging sign came just last week, when President Bush issued an executive order to give federal agencies until the end of 2008 to continue studying the threat of greenhouse gas emissions and determine what can be done about them.

    To us, that again sounds like more of the same inaction and denial, and it is unconscionable.

    Well, the OP-ED says everything that needs to be said. The emperor pretends to forget that even market-based policies (the emperor’s preference) to mitigate climate change need rules, and rules for global warming, which is a global problem, are better off set at the global level. If we cannot get a worldwide agreement together, at least a country wide effort. The emperor has repeated over and over again that he will not pass any regulation in the recent future. So, at least the states are trying, see RGGI for the NorthEast and the West coast. Of course, the emperor is delaying, and denying all he can, yes, it is his responsibility, he is the decider, his administration does what he tells them to do, so there’s no sense in putting anything less than full responsibility on his shoulder.

    California, Connecticut and a host of like-minded states are proving that you can protect the environment and the economy simultaneously.

    It’s high time the federal government becomes our partner or gets out of the way.

    Well said, gubernator, and rellegator!