Drugs in the Water

When researchers analyzed vials of treated wastewater taken from a plant where about 90 Indian drug factories dump their residues, they were shocked. Enough of a single, powerful antibiotic was being spewed into one stream each day to treat every person in a city of 90,000.

And it wasn’t just ciprofloxacin being detected. The supposedly cleaned water was a floating medicine cabinet — a soup of 21 different active pharmaceutical ingredients, used in generics for treatment of hypertension, heart disease, chronic liver ailments, depression, gonorrhea, ulcers and other ailments. Half of the drugs measured at the highest levels of pharmaceuticals ever detected in the environment, researchers say.

Not at all surprising, considering that drug manufacturing releases tons of pollutants at high concentrations. The sources are very different from recent studies in the US where end users of the drug are the greatest source, and ciprofloxacin was again one of the drugs detected at the highest levels. At this rate, most bugs will be resistant to cipro in a few years.

In the end, water treatment plants cannot deal with this toxic soup. They need to be cleaned up at the source, by the pharmaceutical companies before they hit any waste streams. After all, isn’t recapturing and reusing the kilos of drugs being wasted good economic sense?

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  • Salmon linked to Larry Craig's downfall!

    Well, if you believe that correlation = causation, that is! But jokes aside, every time an anti-environmental icon goes down, the salmon rejoice. Not that I know much about fisheries, but salmon and Larry Craig, that’s a great combination right there!

    Sen. Craig’s fall may benefit salmon – Yahoo! News

    The surprising fall of Sen. Larry Craig, R-Idaho, removes a longtime obstacle to efforts by Democrats and environmentalists to promote salmon recovery on Northwest rivers.
    Craig, who was removed from leadership posts on the Senate Appropriations and Energy committees after a sex scandal, is known as one the most powerful voices in Congress on behalf of the timber and power industries. Environmentalists have fought him for years on issues from endangered salmon to public land grazing.

    At issue is the protection of salmon migration trails in Western rivers full of dams. The Bush administration in 2005, among other things, issued a salmon recovery plan that, among other things, counted farmed salmon in claiming that salmon populations were recovering (can’t even be bothered to argue against that!). Craig’s fall will let Harry Reid (Nevada) and Maria Cantwell (Washington) spearhead more sensible legislation.

  • Recycling better than landfilling even to China

    Sending old newspapers and plastic bottles 10,000 miles for recycling in China produces more carbon savings than landfilling it in Britain and making new goods, reveals a study from the government body charged with reducing UK waste.In the last 10 years annual exports of paper, mainly to India, China and Indonesia, have risen from 470,000 tonnes to 4.7m tonnes, while exports of old plastic bottles have gone from under 40,000 tonnes to half a million tonnes.Now the counterintuitive conclusions of the report from the Waste Resources Action Programme (Wrap) suggest that the advantage of recycling over landfilling is so great that it makes environmental sense to ship waste right round the world if it can be used again.

    Waste Resources Action Programme reveals recycling in China saves carbon emissions | Environment | guardian.co.uk

    One of the issues with carbon footprint calculations like these is that they are very dependent on the assumptions made and the calculations used. So, without going through the study line by line, I don’t know if this is true or not, but it is good to know that sending recycling waste many thousands of miles at least does not result in increased resource use. However, the environmental justice implications are still weighted against the receiving country, especially in the recycling of toxic electronic waste. This particular study only dealt with plastic and paper, so the toxic implications were fewer.

    Of course, reducing the stuff you use and reusing your stuff always beats recycling, oh ye iphone lusters, let your old phone die first!

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    An Ode to the Hummer? – Worst Column Ever

    GM desperately needs an obnoxious, attention-grabbing brand to keep from turning into a dreary shadow of its former self. And America needs the Hummer to remind us of what has always made our automobiles stand out, from the tailfin 1950s to the muscle car 1960s and ’70s: swagger. Americans don’t just drive their cars — they proclaim something about themselves by driving them.It takes a certain kind of man — it’s almost always the owner of a Y chromosome — to take a gander at the Hummer, in all its broad, burly, paramilitary gas-guzzling glory, and see himself behind the wheel, striking fear and loathing in the hearts of ecologically sensitive motorists

    Matthew DeBord – Hummer, How We Need Thee – washingtonpost.com

    Yes, and we men need to beat our women and keep them pregnant all the time to avoid turning us men into dreary shadows of our former self.

    Seriously, this is the Washington Post, the newspaper of record of the capital city of the great United States, and this is not a satire. Way to paint the entire American male population as masculinity obsessed rageholics whose only aim is to strike fear in the heart of others while dressed in military fatigues. This man must possess an unhealthy degree of self-hatred to conclude  that disdain of a poorly designed, horrendously inefficient vehicle is somehow hippie and communist.This man is a disgrace to all mankind.

    This, on the other hand is satire

    Ever since we changed our name from British Petroleum to BP (Beyond Petroleum) in 2000, we’ve led the way in developing progressive, environmentally friendly alternatives to gasoline. These last few years of pouring money into biofuels and renewable energy sources have been so great that I can’t for the life of me remember why we used to drill for dirty old oil in the first place! What’s that? You mean we’re still pumping that stuff from hundreds of refineries all over the world?

    Yes, when the Onion is better than the Washington Post, you know your country’s going to the dogs.

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    March Babies not so Bright? – Pesticides to Blame?

    An Indiana scientist makes a rather provocative argument that exposure to pesticides in the womb can explain why Indiana babies conceived in July-August (Born March and April?) have lower achievement scores than the other kids.

    ScienceDaily: Conception Date Affects Babys Future Academic Achievement

    Dr. Winchester and colleagues linked the scores of the students in grades 3 through 10 who took the Indiana Statewide Testing for Educational Progress (ISTEP) examination with the month in which each student had been conceived. The researchers found that ISTEP scores for math and language were distinctly seasonal with the lowest scores received by children who had been conceived in June through August.

    “The fetal brain begins developing soon after conception. The pesticides we use to control pests in fields and our homes and the nitrates we use to fertilize crops and even our lawns are at their highest level in the summer,” said Dr. Winchester, who also directs Newborn Intensive Care Services at St. Francis Hospital in Indianapolis.

    “Exposure to pesticides and nitrates can alter the hormonal milieu of the pregnant mother and the developing fetal brain,” said Dr. Winchester. “While our findings do not represent absolute proof that pesticides and nitrates contribute to lower ISTEP scores, they strongly support such a hypothesis.”

    Well, that is a bold leap of faith, and use of a correlation=causation argument that I don’t appreciate in most cases. Has this kind of work been done in other countries, or in urban environments without pesticide use?

    I am sure that many chemicals have subtle, but significant effects on developing fetuses. And the chemicals the authors mention have links with hypothyroidism..

    Nitrates and pesticides are known to cause maternal hypothyroidism and lower maternal thyroid in pregnancy is associated with lower cognitive scores in offspring.

    There is a link, but without further data, I think the conclusions are a stretch. But, something to keep in mind I guess if you live in Indiana and want to plan a baby!

    Disclaimer: I was conceived in June, and was in the upper echelons of achievement through school. So, by the power of personal experience, I am predisposed to scepticism. OTH, I grew up in a big city with consistently high pollution levels throughout the year and not much pesticide exposure.

  • Drugs in the water: Behold the power of synergy

    funky MathES&T Online News: Can drugs found in water harm humans?

    Researchers agree that aquatic species face the greatest risk from exposure to low levels of pharmaceuticals, such as synthetic hormones, which can act as endocrine disrupters at environmental levels. However, little is known about the potential human health effects arising from complex drug mixtures.

    Well, it is often more difficult to analyze complex mixtures because Experimental Design 101 makes you want to isolate the effects. And when you do compounds one by one in series, the tendency is to always add them up from the individual experiments. Unfortunately, body chemistry is not like that. I’ve always wanted to design a study that started complex and then tried to isolate later.

    To his surprise, Pomati observed that this mixture of drugs at environmental levels inhibited the growth of human embryonic kidney cells. After 48 hours of exposure, cell proliferation was reduced by 10–30% compared with controls. However, no inhibition was observed when cells were exposed to only the toxic cancer drug at environmental levels.

    Well, that seems conclusive enough, but here comes the “Experimental Design 101” Scold:

    The results show that the growth inhibition is not due to the single most cytotoxic compound alone. But that does not conclusively prove that synergistic or additive effects exist between drugs in the mixture, cautions Thomas Heberer of the Institute of Food Chemistry at the Technical University of Berlin. To show that the individual drugs behave additively, Heberer suggests that researchers should analyze the effects of compounds with a common mode of action, such as antibiotics, alone and in various mixtures.

    No, No, and No. Doing this presupposes that you know that mechanism of action, meaning you’ve half answered your question. The question Heberer is trying to answer is “do individual drugs with the same mode of action behave additively”. The question Pomati is trying to answer is “Can we demonstrate cytotoxic effects of a cocktail of drugs at ambient levels in a laboratory setting”? These are two completely different questions and Pomati’s question is more valuable at this point in time. Heberer’s strategy, on the other hand, will keep a lab well funded for years to come! But, it is very much the final step.

    It is more important at this point in time to demonstrate other effects such as endocrine disruption, mutagenicity, etc in the lab at environmentally relevant levels of mixtures. Then we can get a better handle on which  effects are relevant and which ones to ignore.

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    Pollution vs. Development? Hardly!

    It’s clean air vs. TV in poor India village – International Herald Tribune

    Across the developing world, cheap diesel generators from China and elsewhere have become a favorite way to make electricity. They power everything from irrigation pumps to television sets, allowing growing numbers of rural villages in many poor countries to grow more crops and connect to the wider world.

    The headline sucks, clean air vs. TV is not really the choice here. Is the implication that third worlders somehow need to make this a “choice”? It’s not as if the rest of the world has to make this “choice”! They do seem to have both. This is a situation where poor choices are made because of poor infrastructure. Other than the headline, it is a good article because it makes all the right points:

    1. Lack of infrastructure – No centralized power to remote areas
    2. Well meaning, but poorly executed subsidies – Cheap Diesel and Kerosene
    3. Subsidy induced corruption – Diesel/Kerosene pilfering
    4. Top down approaches to development – Throw the money, pay no attention to local experts, don’t follow up, then blame the lazy villagers!
    5. Competition for scarce resources with developed countries – Germany will outpay India for photovoltaics every time.

    Biomass burning as an alternative to diesel?

    Given the popularity of generators, perhaps the most promising alternative is a new type like the one at the edge of the village that contributes much less to air pollution and global warming. It burns a common local weed instead of diesel, costs half as much to operate, emits less pollution and contributes less to global warming.

    The main material is dhaincha, a weed commonly grown in India to restore nitrogen to depleted soils. The dhaincha grows 10 feet tall in just four months, with a three-inch-thick green stalk. Wood from shrubs and trees is used when there is not enough dhaincha.

    I am not a big fan of biomass burning, but using a weed that can be replanted repeatedly seems fairly harmless, especially compared to burning diesel.

    The project has succeeded partly because it has the active backing of one landlord family, the Sharans. Family members have gone on to successful business careers in big Indian cities and in Europe, and have dedicated themselves to helping their home village.

    Local involvement, especially by authority figures goes a long way in rural India.
    China does suggests another way forward.

    China has tried another approach: supplementing an expansion of electricity from coal-fired power plants with cheap rooftop solar water heaters that channel water through thin pipes crisscrossing a shiny surface.

    Close to 5,000 small Chinese companies sell these simple water heaters, and together they have made China the world’s largest market for solar water heaters, with 60 percent of the global market and more than 30 million households using the systems, said Eric Martinot, a renewable energy expert at Tsinghua University in Beijing.

    Not so hot during the monsoon, I guess! I remember a friend of mine having a solar heater in their home in the 1980’s. Their company used to make them, so it is old technology, with price being the prime barrier. It will work as a supplemental source, not as the prime source.

    Clearly, the wider availability and ubiquity of consumer electronics, and electricity-dependent agriculture has outpaced India’s, and to a lesser extent, China’s power infrastructure. It is easy to make a billion television, it’s not quite so easy to keep them powered!