Magic Box under your car makes all your problems go away

ES&T Online News: Can drugs found in water harm humans?

Researchers agree that aquatic species face the greatest risk from exposure to low levels of pharmaceuticals, such as synthetic hormones, which can act as endocrine disrupters at environmental levels. However, little is known about the potential human health effects arising from complex drug mixtures.

Well, it is often more difficult to analyze complex mixtures because Experimental Design 101 makes you want to isolate the effects. And when you do compounds one by one in series, the tendency is to always add them up from the individual experiments. Unfortunately, body chemistry is not like that. I’ve always wanted to design a study that started complex and then tried to isolate later.

To his surprise, Pomati observed that this mixture of drugs at environmental levels inhibited the growth of human embryonic kidney cells. After 48 hours of exposure, cell proliferation was reduced by 10–30% compared with controls. However, no inhibition was observed when cells were exposed to only the toxic cancer drug at environmental levels.

Well, that seems conclusive enough, but here comes the “Experimental Design 101” Scold:

The results show that the growth inhibition is not due to the single most cytotoxic compound alone. But that does not conclusively prove that synergistic or additive effects exist between drugs in the mixture, cautions Thomas Heberer of the Institute of Food Chemistry at the Technical University of Berlin. To show that the individual drugs behave additively, Heberer suggests that researchers should analyze the effects of compounds with a common mode of action, such as antibiotics, alone and in various mixtures.

No, No, and No. Doing this presupposes that you know that mechanism of action, meaning you’ve half answered your question. The question Heberer is trying to answer is “do individual drugs with the same mode of action behave additively”. The question Pomati is trying to answer is “Can we demonstrate cytotoxic effects of a cocktail of drugs at ambient levels in a laboratory setting”? These are two completely different questions and Pomati’s question is more valuable at this point in time. Heberer’s strategy, on the other hand, will keep a lab well funded for years to come! But, it is very much the final step.

It is more important at this point in time to demonstrate other effects such as endocrine disruption, mutagenicity, etc in the lab at environmentally relevant levels of mixtures. Then we can get a better handle on which  effects are relevant and which ones to ignore.

And Dog bites man, yet again, it’s amazing how they keep doing that. Think of all the money being wasted on re-proving the obvious, this is money not spent in mitigating the effects, money not spent on research, money not spent on encouraging people to use more efficient lighting… It’s a shame.

CNN.com – Study: Earth ‘likely’ hottest in 2,000 years – Jun 22, 2006

Climate scientists Michael Mann, Raymond Bradley and Malcolm Hughes had concluded the Northern Hemisphere was the warmest it has been in 2,000 years. Their research was known as the “hockey-stick” graphic because it compared the sharp curve of the hockey blade to the recent uptick in temperatures and the stick’s long shaft to centuries of previous climate stability.

The National Academy scientists concluded that the Mann-Bradley-Hughes research from the late 1990s was “likely” to be true, said John “Mike” Wallace, an atmospheric sciences professor at the University of Washington and a panel member. The conclusions from the ’90s research “are very close to being right” and are supported by even more recent data, Wallace said.

The panel looked at how other scientists reconstructed the Earth’s temperatures going back thousands of years, before there was data from modern scientific instruments.

For all but the most recent 150 years, the academy scientists relied on “proxy” evidence from tree rings, corals, glaciers and ice cores, cave deposits, ocean and lake sediments, boreholes and other sources. They also examined indirect records such as paintings of glaciers in the Alps.

Combining that information gave the panel “a high level of confidence that the last few decades of the 20th century were warmer than any comparable period in the last 400 years,” the academy said.

Where for the n’th time, you get to use “EPA”, and “scales back rules” in one sentence.

E.P.A. Scaled Back Rules on Wetlands – New York Times

After a concerted lobbying effort by property developers, mine owners and farm groups, the Bush administration scaled back proposed guidelines for enforcing a key Supreme Court ruling governing protected wetlands and streams. The administration last fall prepared broad new rules for interpreting the decision, handed down by a divided Supreme Court in June 2006, that could have brought thousands of small streams and wetlands under the protection of the Clean Water Act of 1972. The draft guidelines, for example, would allow the government to protect marsh lands and temporary ponds that form during heavy rains if they could potentially affect water quality in a nearby navigable waterway. But just before the new guidelines were to be issued last September, they were pulled back in the face of objections from lobbyists and lawyers for groups concerned that the rules could lead to federal protection of isolated and insignificant swamps, potholes and ditches.

This is the consequence of a tortured Supreme Court ruling from June of last year where Justice Kennedy could not make up his mind on what was a wetland and what was not, so he helped hand down a very confusing verdict open to all kinds of interpretation. At that time, here’s what I said…

This will make things confusing for a while, and you all know who confusion favors!

Well, I told ya!

Yes, strained headline!

A Toxic Hand-Me-Down — Balter 2007 (327): 1 — ScienceNOW

Environmental contamination can cause cancer and birth defects. Of particular concern are a group of toxic chemicals called endocrine-disrupters, which interfere with reproductive hormones and may cause sterility. A new study, published online this week in the Proceedings of the National Academy of Sciences, suggests that these chemicals can change reproductive behavior as well, and that these behavioral changes can be passed on from parents to offspring. If correct, these changes could alter the course of evolution by giving natural selection new targets to act on.

In 2005, a team led by reproductive biologist Michael Skinner of Washington State University in Pullman reported in Science that the fungicide vinclozolin, an endocrine-disrupter used to spray vineyards and other crops, causes fertility defects in the male offspring of female rats treated with the chemical. These defects are, in turn, passed down to the males of subsequent generations. The toxin did not appear to be altering gene sequences; instead, Skinner and colleagues found, vinclozolin was somehow causing other chemical groups to latch onto certain genes, changing their expression (Science, 3 June 2005, p. 1391). The phenomenon is known as epigenetic inheritance. Last year, Skinner’s group identified 15 epigenetically altered DNA sequences in the sperm of the vinclozolin-treated rats

More signs of intergenerational effects of low levels of endocrine disruptors. I had blogged recently about Bisphenol A having intergenerational effects (where exposure to a chemical agent causes consequences for offspring and off off spring, etc).

It’s still early, but remember Children of Men (good movie, see it).

In case you did not know already, the IPCC is very close to releasing its report on climate change impacts.

BBC NEWS | Science/Nature | Climate change ‘to hit poor hard’

Dr Parry outlined the four areas of the world now thought to be the most vulnerable to climate change. “The arctic, where temperatures are rising fast and ice is melting; sub-Saharan Africa, where dry areas are forecast to get dryer; small islands, because of their inherent lack of capacity to adapt and Asian mega-deltas, where billions of people will be at increased risk of flooding,” he explained. As a result, the most severe impacts will be felt by the world’s poorest countries, the report says. “The poorest of the poor in the world… are going to be the worst hit and are the most vulnerable in terms of impact of climate change,” said IPCC chairman Rajendra Pachauri. Mr Pachauri said those people were also the least equipped to deal with the effects of such changes. Scientists and government officials from more than 100 countries met through the night, trying to agree on the wording of a summary for policy makers. Several delegations, including the US, Saudi Arabia, China and India, had asked for the final version to reflect less certainty than the draft.

The U.S objected to the contention that climate change would cause severe economic damage in the United States, China wanted to reduce the certainty applied to these changes, and I have no idea what India would object to, since it stands to lose a great deal. But as usual, the  people who have the most to lose are not the ones doing the negotiating, so I guess that is to be expected.